{"id":"W2163669036","doi":"10.1016/j.jmb.2014.01.004","title":"O-GlcNAc Modification of tau Directly Inhibits Its Aggregation without Perturbing the Conformational Properties of tau Monomers","year":2014,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":139,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; Simon Fraser University","funders":"Canadian Institutes of Health Research; British Columbia Knowledge Development Fund; Michael Smith Health Research BC; Natural Sciences and Engineering Research Council of Canada; Alzheimer Society","keywords":"Chemistry; Monomer; Tau protein; Stereochemistry; Biophysics; Biology; Medicine; Polymer; Organic chemistry; Alzheimer's disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007397066,0.0001086335,0.0002130468,0.000128944,0.00005435672,0.000010649,0.0002443935,0.0001404197,0.00001065518],"category_scores_gemma":[0.0006253816,0.000071927,0.0001270706,0.0001106567,0.000170738,0.00001328888,0.00005668704,0.0001370187,0.000002286878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000162231,"about_ca_system_score_gemma":0.0001429546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001252317,"about_ca_topic_score_gemma":0.000003851721,"domain_scores_codex":[0.9987013,0.0002692459,0.0005440857,0.0001190715,0.0002192594,0.0001470221],"domain_scores_gemma":[0.9983339,0.00002027075,0.0006442295,0.0001921298,0.0007562101,0.00005320875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001828316,0.00003841413,0.0005430028,0.00003618629,0.00007155679,2.219074e-7,0.0001292978,0.0006459086,0.9914792,0.0009406177,0.00003992156,0.005892901],"study_design_scores_gemma":[0.000594854,0.0004659525,0.0007953898,0.00004812434,0.00001682383,0.00003261231,0.00009252106,0.001490677,0.9931832,0.0001313854,0.003068543,0.00007990637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846321,0.001553147,0.012538,0.0006018573,0.00007790634,0.000208829,0.000006017063,0.000002191809,0.0003799872],"genre_scores_gemma":[0.9990156,0.0001592251,0.000523529,0.0001124001,0.00007757145,0.000008131349,0.00002780048,0.00001018551,0.00006556798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01438352,"threshold_uncertainty_score":0.2933098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02184620617728082,"score_gpt":0.2820821668571007,"score_spread":0.2602359606798199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}