{"id":"W2163669274","doi":"10.1152/ajpheart.00476.2008","title":"Role of endothelial nitric oxide synthase-derived nitric oxide in activation and dysfunction of cerebrovascular endothelial cells during early onsets of sepsis","year":2008,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute","funders":"Heart and Stroke Foundation of Canada","keywords":"Nitric oxide; Endothelial nitric oxide synthase; Nitric oxide synthase; Endothelial dysfunction; Sepsis; Endothelial stem cell; Medicine; Internal medicine; Chemistry; Pharmacology; Cardiology; Biochemistry; Enos; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003042897,0.0002554215,0.0003458867,0.0002297878,0.0001554892,0.0002211004,0.0001488371,0.0004093315,0.0003606193],"category_scores_gemma":[0.0003009252,0.0001087452,0.0001654031,0.00009467534,0.0002235926,0.0001938008,0.0001771666,0.0005232146,0.00008477191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001740104,"about_ca_system_score_gemma":0.0001570782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001862661,"about_ca_topic_score_gemma":0.0002687359,"domain_scores_codex":[0.9998589,0.00005221773,0.00001409092,0.00001971676,0.0000235969,0.00003150164],"domain_scores_gemma":[0.999797,0.00002148524,0.00007570745,0.00001294682,0.0000256186,0.00006722049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002155704,0.000168904,0.00619577,0.0002124793,0.00002400686,0.00192192,0.0001798656,0.00006623515,0.984628,0.000178868,0.00008849298,0.004179651],"study_design_scores_gemma":[0.0001602246,0.004339904,0.411247,0.0001424903,0.0001553709,0.006834875,0.0006276488,0.00244936,0.5703694,0.0006029838,0.003030123,0.00004064224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935533,0.004896058,0.0008473012,0.00008509518,0.0000266389,0.00001915466,0.00007056091,0.00001547166,0.0004863946],"genre_scores_gemma":[0.9973636,0.00162317,0.0005805255,0.00005253265,0.00002910698,0.00002698438,0.00007334821,0.000001950265,0.0002487038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004093315,"threshold_uncertainty_score":0.001609266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007885832072650178,"score_gpt":0.2156065383559779,"score_spread":0.2077207062833278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}