{"id":"W2163671742","doi":"10.1097/aln.0000000000000732","title":"Malignant Hyperthermia Testing in Probands without Adverse Anesthetic Reaction","year":2015,"lang":"en","type":"article","venue":"Anesthesiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Office of the Chief Medical Examiner; Ontario Medical Association; Canadian Nurses Association; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Malignant hyperthermia; Dantrolene; Rhabdomyolysis; Exercise intolerance; Creatine kinase; Anesthesia; Anesthetic; Etiology; Proband; Adverse effect; Placebo; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002760533,0.0001176491,0.0001312004,0.0000721901,0.00003297573,0.000004184069,0.00007316002,0.0001900386,0.000005260551],"category_scores_gemma":[0.0001534185,0.0001019894,0.00003172234,0.0001217177,0.00005620249,0.000005670566,0.00002096054,0.00006698992,0.00004492302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002300337,"about_ca_system_score_gemma":0.00008008724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006106913,"about_ca_topic_score_gemma":0.00002998966,"domain_scores_codex":[0.9991629,0.0001099278,0.0001830518,0.000275391,0.0000717691,0.0001970092],"domain_scores_gemma":[0.9995615,0.00001089542,0.00007274077,0.0001884639,0.00009504328,0.00007129563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006801678,0.0001610822,0.6869828,0.00001615375,0.00001381223,0.00006886209,0.0003418056,0.001895519,0.2990141,0.000146444,0.0009443742,0.009734862],"study_design_scores_gemma":[0.005497259,0.004176477,0.7659858,0.00009145009,0.00004116771,0.003328781,0.001378851,0.005399961,0.05403794,0.001434974,0.1575074,0.001119926],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983002,0.00009375759,0.00005083819,0.00009900835,0.0001913842,0.0001484285,3.47553e-7,0.00002493261,0.001091113],"genre_scores_gemma":[0.9983322,0.00001098892,0.0003056882,0.0003505588,0.0002323764,0.00002949637,0.000055275,0.00001758836,0.0006658036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2449762,"threshold_uncertainty_score":0.4159007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03961618358121424,"score_gpt":0.2548367434448175,"score_spread":0.2152205598636033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}