{"id":"W2163671742","doi":"10.1097/aln.0000000000000732","title":"Malignant Hyperthermia Testing in Probands without Adverse Anesthetic Reaction","year":2015,"lang":"en","type":"article","venue":"Anesthesiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Office of the Chief Medical Examiner; Ontario Medical Association; Canadian Nurses Association; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Malignant hyperthermia; Dantrolene; Rhabdomyolysis; Exercise intolerance; Creatine kinase; Anesthesia; Anesthetic; Etiology; Proband; Adverse effect; Placebo; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004514933,0.0006301707,0.0003079656,0.001298586,0.0007705652,0.0003585646,0.0004238078,0.000625838,0.002332672],"category_scores_gemma":[0.002691425,0.0001833215,0.0002331977,0.0005429555,0.0006698661,0.0003550581,0.0005137454,0.0004680571,0.0003111846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002848662,"about_ca_system_score_gemma":0.0003816907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002107462,"about_ca_topic_score_gemma":0.001757983,"domain_scores_codex":[0.9994237,0.0001168703,0.00006984251,0.0001164751,0.00012417,0.000148962],"domain_scores_gemma":[0.9987155,0.0004449617,0.000377503,0.00004217091,0.0001161271,0.0003037678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001729306,0.00005200629,0.9437147,0.00002903076,0.00000898364,0.04974222,0.0003427398,0.00005863508,0.003462986,0.0000522948,0.000244403,0.002119088],"study_design_scores_gemma":[0.00002167373,0.0006276804,0.7861676,0.0000552066,0.00006655238,0.2077451,0.001038535,0.0004912277,0.002881079,0.0001150666,0.0007778313,0.00001256862],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998538,0.0002805727,0.0001742534,0.00008984479,0.00001123555,0.00001926562,0.00007254534,0.000009004341,0.0008053604],"genre_scores_gemma":[0.9994941,0.0001146863,0.0001548972,0.00004693249,0.00001684505,0.000006933794,0.00006935166,0.000002525799,0.00009377832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002332672,"threshold_uncertainty_score":0.0078035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03961618358121424,"score_gpt":0.2548367434448175,"score_spread":0.2152205598636033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}