{"id":"W2163705190","doi":"10.1152/ajprenal.00119.2005","title":"Mesangial cell NADPH oxidase upregulation in high glucose is protein kinase C dependent and required for collagen IV expression","year":2005,"lang":"en","type":"article","venue":"American Journal of Physiology-Renal Physiology","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs","funders":"","keywords":"Downregulation and upregulation; NADPH oxidase; Chemistry; Cell biology; Glucose oxidase; Mesangial cell; Protein kinase A; Kinase; Biochemistry; Enzyme; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001122186,0.00028754,0.0002365624,0.0001990785,0.0001641905,0.0002393386,0.0001232617,0.0002270172,0.00119188],"category_scores_gemma":[0.00007902221,0.0001322711,0.0002904628,0.0001741183,0.00016283,0.0001631906,0.0001380815,0.0005937489,0.0003225278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003040101,"about_ca_system_score_gemma":0.000180449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001195679,"about_ca_topic_score_gemma":0.001774367,"domain_scores_codex":[0.9998678,0.00001603507,0.000009726228,0.00003019596,0.00003448007,0.00004175978],"domain_scores_gemma":[0.9999042,0.000007537496,0.00002435743,0.00001121177,0.00001314718,0.00003968326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009861698,0.00001985603,0.0003523611,0.00002114853,0.000003363351,0.0001001441,0.000006735777,0.00001183783,0.9988562,0.00002859653,0.00002386558,0.0004773847],"study_design_scores_gemma":[0.00002334657,0.0003507003,0.04370135,0.000008305348,0.00002635478,0.0004690462,0.00005938075,0.0005048551,0.9526032,0.00006431327,0.00218317,0.000006062425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935073,0.001994121,0.00246267,0.0001502132,0.00005825773,0.00003282427,0.0003815313,0.00006888146,0.001344246],"genre_scores_gemma":[0.9942198,0.001011013,0.002069463,0.00005623945,0.00002902732,0.00003599568,0.0005105668,0.00000898729,0.002058922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001195679,"threshold_uncertainty_score":0.003987253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008187033222746172,"score_gpt":0.2734814567780876,"score_spread":0.2652944235553414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}