{"id":"W2163727429","doi":"10.1093/jac/dkh294","title":"Type II topoisomerase mutations in Bacillus anthracis associated with high-level fluoroquinolone resistance","year":2004,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital","funders":"","keywords":"Efflux; Bacillus anthracis; Ofloxacin; Microbiology; Broth microdilution; Topoisomerase IV; DNA gyrase; Biology; Quinolone; Levofloxacin; Gene; Bacteria; Antibiotics; Genetics; Escherichia coli; Ciprofloxacin; Minimum inhibitory concentration","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002674321,0.0001589333,0.0002800051,0.0001144124,0.0001081641,0.0000331076,0.0002111466,0.0001621232,0.00005893446],"category_scores_gemma":[0.0001062989,0.0001318896,0.00008297621,0.0003128264,0.000136725,0.00001670636,0.00002772779,0.0002076456,0.000003098324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008525805,"about_ca_system_score_gemma":0.0003240263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000310626,"about_ca_topic_score_gemma":0.0003446008,"domain_scores_codex":[0.9989176,0.00004440135,0.0003712032,0.0001884641,0.000192095,0.0002861816],"domain_scores_gemma":[0.9990908,0.00001273076,0.0002423919,0.0001712314,0.000398452,0.0000843735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001795784,0.0003566166,0.0002644187,0.00001026148,0.0001045971,0.00005027459,0.0001908744,0.0002669458,0.9950565,0.00002226578,0.0008696063,0.001011884],"study_design_scores_gemma":[0.008462362,0.001515621,0.009648364,0.0002349891,0.00001814304,0.00008103139,0.00003821481,0.000001601089,0.9732664,0.0001283793,0.006299723,0.0003052141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969594,0.0002547844,0.0004617607,0.001856297,0.0001756863,0.0001207517,0.00004072245,0.000004250566,0.0001263403],"genre_scores_gemma":[0.9958156,0.0008076777,0.002254833,0.0004074573,0.0001837211,0.000001062329,0.00004406416,0.00002907507,0.0004564751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02179011,"threshold_uncertainty_score":0.53783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01398504150808267,"score_gpt":0.2516835638197433,"score_spread":0.2376985223116607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}