{"id":"W2163756947","doi":"10.4049/jimmunol.1001261","title":"PTPα Activates Lyn and Fyn and Suppresses Hck to Negatively Regulate FcεRI-Dependent Mast Cell Activation and Allergic Responses","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"LYN; Syk; FYN; Src family kinase; Phosphorylation; Cell biology; Mast cell; Chemistry; Immunoglobulin E; Tyrosine-protein kinase CSK; Kinase; Signal transduction; Tyrosine phosphorylation; Protein tyrosine phosphatase; Proto-oncogene tyrosine-protein kinase Src; Tyrosine kinase; Immunology; Biology; SH2 domain; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005554452,0.0001843804,0.0003337049,0.000188262,0.0002720156,0.00002954033,0.0002033291,0.0002159275,0.0002468624],"category_scores_gemma":[0.0001685219,0.0001221456,0.00002983067,0.00007034218,0.0005446363,0.0001598673,0.0002006968,0.0006499175,0.00001164442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000128316,"about_ca_system_score_gemma":0.00004559875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007923534,"about_ca_topic_score_gemma":0.00004974685,"domain_scores_codex":[0.9988571,0.0003371291,0.0003457492,0.0001629613,0.00004206189,0.0002549368],"domain_scores_gemma":[0.9986322,0.000655025,0.0003494063,0.0001949732,0.0001307647,0.00003764068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00253304,0.00005770673,0.0004269934,0.00001392337,0.0001535336,0.000005235998,0.001816912,0.000002853253,0.9911064,0.0002264399,0.0004267789,0.003230188],"study_design_scores_gemma":[0.002009023,0.001025435,0.08059801,0.00004031521,0.00007757412,0.00149887,0.001392067,0.000002155644,0.8782113,0.0004873969,0.03447906,0.0001788154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926395,0.003852035,0.00005415949,0.002617024,0.000369963,0.000149897,0.00001014303,0.00001016644,0.0002971201],"genre_scores_gemma":[0.9946721,0.001727443,0.0001778266,0.0001371361,0.00004181842,0.000002470212,0.000002632961,0.00001555132,0.003223019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1128951,"threshold_uncertainty_score":0.4980951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007653514456293605,"score_gpt":0.214077066757302,"score_spread":0.2064235523010083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}