{"id":"W2163756947","doi":"10.4049/jimmunol.1001261","title":"PTPα Activates Lyn and Fyn and Suppresses Hck to Negatively Regulate FcεRI-Dependent Mast Cell Activation and Allergic Responses","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"LYN; Syk; FYN; Src family kinase; Phosphorylation; Cell biology; Mast cell; Chemistry; Immunoglobulin E; Tyrosine-protein kinase CSK; Kinase; Signal transduction; Tyrosine phosphorylation; Protein tyrosine phosphatase; Proto-oncogene tyrosine-protein kinase Src; Tyrosine kinase; Immunology; Biology; SH2 domain; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001581764,0.0003246432,0.0001991404,0.0001762201,0.0001279427,0.0002166413,0.00013436,0.0001652557,0.001193485],"category_scores_gemma":[0.0001354787,0.0001239309,0.0002876009,0.0001085515,0.0001871375,0.0001821881,0.0002710745,0.0005156853,0.000365994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002688809,"about_ca_system_score_gemma":0.0001898296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005204997,"about_ca_topic_score_gemma":0.0004831868,"domain_scores_codex":[0.9998091,0.00002608916,0.00001765992,0.00004406891,0.00004738259,0.00005566335],"domain_scores_gemma":[0.9999145,0.000005370606,0.00003318523,0.000007655412,0.00001135994,0.00002793586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006159733,0.000009352744,0.0001861787,0.0000202137,0.000003524524,0.00004681602,0.000006561853,0.0000283556,0.9987772,0.00005035441,0.00002069835,0.0007890799],"study_design_scores_gemma":[0.00003888646,0.0002951941,0.02184525,0.00001166108,0.00002711524,0.000949953,0.00003754877,0.0009904449,0.9723634,0.0001225141,0.003313558,0.000004539557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907045,0.004014172,0.003336637,0.0001088653,0.00005037498,0.00002651721,0.0002120551,0.00005846449,0.001488345],"genre_scores_gemma":[0.9950863,0.001534572,0.0008605291,0.00005333275,0.00001846111,0.00002433564,0.0002858299,0.00001061557,0.00212597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001193485,"threshold_uncertainty_score":0.003992617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007653514456293605,"score_gpt":0.214077066757302,"score_spread":0.2064235523010083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}