{"id":"W2163769371","doi":"10.1186/1475-2840-13-89","title":"High glucose induces Smad activation via the transcriptional coregulator p300 and contributes to cardiac fibrosis and hypertrophy","year":2014,"lang":"en","type":"article","venue":"Cardiovascular Diabetology","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Diabetic cardiomyopathy; Curcumin; SMAD; Cardiac fibrosis; Medicine; Internal medicine; Endocrinology; Transforming growth factor; Fibrosis; Heart failure; Myocardial fibrosis; Cardiomyopathy; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005518659,0.0002269915,0.0009978386,0.0001293689,0.0002119597,0.00004482215,0.00006741151,0.000227608,0.000004422673],"category_scores_gemma":[0.0001394605,0.0001586573,0.0005789591,0.0001968961,0.0002863838,0.00007181424,0.00006164085,0.0001994871,0.000005766916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000461083,"about_ca_system_score_gemma":0.00003149101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007082134,"about_ca_topic_score_gemma":9.896264e-7,"domain_scores_codex":[0.9984384,0.0002432884,0.0002536724,0.0004687557,0.0002764625,0.0003193841],"domain_scores_gemma":[0.9989583,0.0001931212,0.00004090288,0.0004759628,0.0001635075,0.0001682346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002871788,0.00005205442,0.02175169,0.0001987041,0.004789709,0.000002438329,0.0002925852,0.0006346839,0.7935134,0.004544048,0.0003816987,0.1735518],"study_design_scores_gemma":[0.00245864,0.0002264732,0.8901828,0.0001216493,0.001979919,0.00006533874,0.0001096407,0.0006909314,0.05990326,0.0007479904,0.04316966,0.0003436824],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.971732,0.01623387,0.008854683,0.002015813,0.0004939595,0.0005685475,0.0000182711,0.00004467875,0.00003822755],"genre_scores_gemma":[0.9976625,0.0004140598,0.0006888693,0.0006567056,0.0004144596,0.00007156905,0.00004797646,0.000030876,0.00001300136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8684311,"threshold_uncertainty_score":0.6469856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008289627589271372,"score_gpt":0.2019344688769527,"score_spread":0.1936448412876813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}