{"id":"W2163787552","doi":"10.1084/jem.20072681","title":"The failed HIV Merck vaccine study: a step back or a launching point for future vaccine development?","year":2008,"lang":"en","type":"letter","venue":"The Journal of Experimental Medicine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":396,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"HIV vaccine; Virology; AIDS Vaccines; Human immunodeficiency virus (HIV); Medicine; Immunology; Vaccine trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001419993,0.0005930234,0.001154495,0.0002186541,0.001018204,0.00002366605,0.001080489,0.0003701579,0.001509634],"category_scores_gemma":[0.0001763407,0.0002257837,0.0002141938,0.0001813314,0.0001733968,0.00009790611,0.0002076524,0.002212033,0.0002569185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003386523,"about_ca_system_score_gemma":0.0003576596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004502332,"about_ca_topic_score_gemma":0.00005896073,"domain_scores_codex":[0.9964272,0.0008504939,0.001268573,0.0002977578,0.0003603243,0.0007956464],"domain_scores_gemma":[0.9967679,0.001444873,0.0008772172,0.0005627632,0.0002641874,0.00008306668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006385015,0.0004271575,0.0001137327,0.00003469402,0.003024557,0.0004923582,0.009828823,2.530129e-7,0.007631616,0.000001427873,0.9702374,0.001822978],"study_design_scores_gemma":[0.01805529,0.007352002,0.0003441656,0.000387932,0.0003499018,0.002333594,0.01988732,6.379786e-7,0.007135827,0.000004933643,0.9438933,0.00025506],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.08209103,0.1365091,0.0001932312,0.7716006,0.004434584,0.004669188,0.00006617721,0.00004140554,0.0003947127],"genre_scores_gemma":[0.4594209,0.0198404,0.002596796,0.317608,0.0465738,0.00127074,0.002935926,0.0008725745,0.1488808],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.4539925,"threshold_uncertainty_score":0.9994031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0277286224728915,"score_gpt":0.3081849565549724,"score_spread":0.2804563340820809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}