{"id":"W2163824921","doi":"10.4049/jimmunol.167.2.655","title":"Expansion of the Antigenic Repertoire of a Single T Cell Receptor upon T Cell Activation","year":2001,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia; University of Alberta; University of Calgary","funders":"","keywords":"T-cell receptor; Biology; Avidity; Cytotoxic T cell; CD28; T cell; CD8; Cell biology; Antigen; Population; Major histocompatibility complex; Molecular biology; Immunology; In vitro; Immune system; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007085705,0.0002233077,0.0005798272,0.0001956386,0.0002282937,0.00000397442,0.0009509249,0.0004346911,0.0005434299],"category_scores_gemma":[0.0001347908,0.0001253469,0.0003045156,0.0003485492,0.0006841138,0.0001275293,0.000217686,0.000756195,0.00005824629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006576434,"about_ca_system_score_gemma":0.0001785416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001454182,"about_ca_topic_score_gemma":0.000009936422,"domain_scores_codex":[0.9973212,0.001052115,0.001018651,0.0001526027,0.00008561157,0.0003698595],"domain_scores_gemma":[0.9966958,0.0004525443,0.001821456,0.0006584474,0.000358929,0.00001286933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001578443,0.0005209876,0.0004258944,0.00001972428,0.0002100874,0.000001799226,0.001251778,0.0000315971,0.9923079,0.00004317438,0.001039162,0.002569434],"study_design_scores_gemma":[0.001943869,0.001380749,0.001050459,0.0000925802,0.000117916,0.0004657407,0.001478515,0.000001238926,0.9778943,0.0001311332,0.01532465,0.0001188378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985485,0.010718,0.0001379619,0.0008063207,0.001621244,0.0001888198,0.000004884253,0.00001215343,0.0010256],"genre_scores_gemma":[0.9948013,0.002574296,0.00006399897,0.00008284207,0.00004283131,0.000001669711,0.00000591827,0.0000223934,0.002404738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0144136,"threshold_uncertainty_score":0.5950177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01221189828583885,"score_gpt":0.207824493648527,"score_spread":0.1956125953626882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}