{"id":"W2163880258","doi":"10.1128/mcb.21.16.5591-5604.2001","title":"SATB1 Cleavage by Caspase 6 Disrupts PDZ Domain-Mediated Dimerization, Causing Detachment from Chromatin Early in T-Cell Apoptosis","year":2001,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"National Cancer Institute; National Institutes of Health; National Institute of General Medical Sciences; Institut Du Cancer de Montréal","keywords":"Biology; Chromatin; PDZ domain; Cell biology; Molecular biology; Cleavage (geology); Jurkat cells; DNA; Xenopus; DNA-binding protein; Genetics; Gene; Transcription factor; T cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009567049,0.0001986706,0.000312507,0.0001217849,0.00008057709,0.00002355746,0.00004723811,0.0001657323,0.0001432502],"category_scores_gemma":[0.00003260633,0.0001830662,0.00007706017,0.0002117169,0.00007908085,0.00003624599,0.00004526869,0.0001984674,0.00002544463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005014064,"about_ca_system_score_gemma":0.00003049715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001347817,"about_ca_topic_score_gemma":0.00003056055,"domain_scores_codex":[0.9987643,0.0001221227,0.000336572,0.0003845857,0.00009808694,0.0002943111],"domain_scores_gemma":[0.9994556,0.00004639847,0.00009058545,0.0002275368,0.00003400619,0.0001459283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006803487,0.0002019854,0.01657678,0.00001144422,0.00004399117,0.0002054426,0.0003133377,0.000003681204,0.9819481,0.00002710253,0.0001712017,0.0004289467],"study_design_scores_gemma":[0.001862882,0.0003820634,0.002226474,0.00005750234,0.0000834437,0.00003635799,0.0001541979,0.0002234459,0.9867735,0.0001227785,0.007842992,0.0002343881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828244,0.001540325,0.01404214,0.0004161677,0.0001511765,0.0002671103,0.00005701166,0.00003794105,0.0006637155],"genre_scores_gemma":[0.9976017,0.0001227769,0.0003954778,0.0005424769,0.00006679614,0.00002150844,0.001153489,0.00002800543,0.00006778171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01477728,"threshold_uncertainty_score":0.7465224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006818059082809916,"score_gpt":0.2372296468466971,"score_spread":0.2304115877638872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}