{"id":"W2163880258","doi":"10.1128/mcb.21.16.5591-5604.2001","title":"SATB1 Cleavage by Caspase 6 Disrupts PDZ Domain-Mediated Dimerization, Causing Detachment from Chromatin Early in T-Cell Apoptosis","year":2001,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"National Cancer Institute; National Institutes of Health; National Institute of General Medical Sciences; Institut Du Cancer de Montréal","keywords":"Biology; Chromatin; PDZ domain; Cell biology; Molecular biology; Cleavage (geology); Jurkat cells; DNA; Xenopus; DNA-binding protein; Genetics; Gene; Transcription factor; T cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001171206,0.0002519534,0.0001385944,0.0001300286,0.0001214763,0.0001995567,0.0001818148,0.0002856546,0.001681766],"category_scores_gemma":[0.0001285913,0.0001478227,0.0002384289,0.0001067483,0.0001728785,0.0001523691,0.0001530001,0.0007361647,0.0004322244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002607121,"about_ca_system_score_gemma":0.0001299731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003017189,"about_ca_topic_score_gemma":0.0004011606,"domain_scores_codex":[0.9998804,0.00001897247,0.00001135565,0.00002680483,0.00002852165,0.00003392286],"domain_scores_gemma":[0.9998679,0.00002741271,0.00004772443,0.00001484409,0.000007848983,0.00003424168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004817678,0.00001127703,0.0001331008,0.00001014851,0.000003036935,0.00002946224,0.000005946381,0.00002688491,0.9994266,0.00003653367,0.000009477041,0.0002593878],"study_design_scores_gemma":[0.00001407163,0.0001316477,0.004231855,0.00000265927,0.00000596355,0.000332574,0.00001721386,0.000710949,0.9939243,0.00003433275,0.000592056,0.000002357751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970815,0.000603916,0.001709738,0.00004772902,0.00001172569,0.0000105018,0.0001422569,0.0000201441,0.0003725693],"genre_scores_gemma":[0.9969259,0.0002468012,0.001419492,0.00003440079,0.000003294371,0.00001101529,0.0004504299,0.000007277388,0.0009014422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001681766,"threshold_uncertainty_score":0.005626082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006818059082809916,"score_gpt":0.2372296468466971,"score_spread":0.2304115877638872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}