{"id":"W2163892917","doi":"10.2337/db08-0485","title":"Small Interfering RNA–Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture","year":2008,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Child and Family Research Institute; McGill University; University of British Columbia","funders":"National Center for Research Resources","keywords":"Islet; Small interfering RNA; Amyloid (mycology); Amylin; Beta cell; Biology; Cell culture; Endocrinology; Internal medicine; Pancreatic islets; Apoptosis; Insulin; Molecular biology; Cell biology; Transfection; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002645552,0.0004749905,0.0004361323,0.0001683144,0.0001387164,0.0004253482,0.0003174268,0.0002070584,0.0009469999],"category_scores_gemma":[0.0001316176,0.0001199807,0.0002687615,0.0001409601,0.0001982008,0.0001235654,0.0001324209,0.0005096763,0.0004727848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002332034,"about_ca_system_score_gemma":0.0001917139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003396199,"about_ca_topic_score_gemma":0.0005523441,"domain_scores_codex":[0.9997587,0.00003761615,0.00003417048,0.00005347149,0.00007675853,0.00003934484],"domain_scores_gemma":[0.9998608,0.00005066095,0.00002743103,0.00002192175,0.00001774682,0.00002145999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001032649,0.00005943354,0.00008380107,0.0000260833,0.000005535451,0.00002879214,0.00002055697,0.00005392862,0.9984983,0.00002993726,0.00006879837,0.001021351],"study_design_scores_gemma":[0.00002859675,0.0004645601,0.001607774,0.000004730613,0.00002266266,0.0001340212,0.00001431938,0.001264892,0.9946583,0.00001131023,0.001785994,0.000002869541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903786,0.001942959,0.004362823,0.00007704768,0.00007641791,0.00006319782,0.0004088548,0.0001672623,0.002522721],"genre_scores_gemma":[0.9853018,0.001993908,0.006823534,0.00008305962,0.00003675649,0.0001536788,0.001404937,0.00005428343,0.004148087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009469999,"threshold_uncertainty_score":0.003168046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02346864534627978,"score_gpt":0.2468103938624516,"score_spread":0.2233417485161718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}