{"id":"W2163894821","doi":"10.1158/0008-5472.can-03-3038","title":"Hypoxia Enhances Metastatic Efficiency by Up-Regulating Mdm2 in KHT Cells and Increasing Resistance to Apoptosis","year":2004,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"National Institute on Aging","keywords":"Mdm2; Hypoxia (environmental); Apoptosis; Cancer research; Transactivation; Transfection; Biology; Programmed cell death; Tumor hypoxia; Metastasis; Gene; Chemistry; Transcription factor; Internal medicine; Medicine; Cancer; Genetics; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000597578,0.0001252632,0.0001568302,0.0001663396,0.0001141457,0.000165562,0.00005628235,0.0001213649,0.001381478],"category_scores_gemma":[0.00007637999,0.00007383421,0.0001458303,0.0001073815,0.0001050242,0.00008593622,0.00009491834,0.0002055487,0.0002534914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001558331,"about_ca_system_score_gemma":0.00007680603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007405988,"about_ca_topic_score_gemma":0.001044547,"domain_scores_codex":[0.9999415,0.00001099775,0.000005884182,0.000007235059,0.00001737389,0.0000170249],"domain_scores_gemma":[0.9999506,0.00001212363,0.0000101364,0.000007226195,0.000005424535,0.00001435496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005432468,0.00001655059,0.00031948,0.00001135504,0.000001783469,0.00003554805,0.000007787171,0.00002919188,0.9988753,0.00003217698,0.00003761927,0.0005788631],"study_design_scores_gemma":[0.00003164023,0.0007907845,0.02944323,0.000005129596,0.00001330521,0.0007541574,0.00004742601,0.001250998,0.9641215,0.00006493746,0.003471542,0.000005292648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973937,0.0008002383,0.0005226008,0.00005433497,0.000008850919,0.00001277274,0.0001616794,0.00002707185,0.001018743],"genre_scores_gemma":[0.9970427,0.0004942993,0.0006467747,0.00003132884,0.000007855579,0.00001781511,0.0002974372,0.000006426493,0.001455347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001381478,"threshold_uncertainty_score":0.004621506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02543967524051021,"score_gpt":0.3424657106104671,"score_spread":0.3170260353699569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}