{"id":"W2163901561","doi":"10.1111/j.1365-2133.2008.08487.x","title":"Efficacy and safety of oral alitretinoin (9-cis retinoic acid) in patients with severe chronic hand eczema refractory to topical corticosteroids: results of a randomized, double-blind, placebo-controlled, multicentre trial","year":2008,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Contact Dermatitis and Allergies","field":"Medicine","cited_by":408,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada); Lynde Centre for Dermatology","funders":"","keywords":"Medicine; Placebo; Refractory (planetary science); Adverse effect; Randomized controlled trial; Internal medicine; Placebo-controlled study; Clinical trial; Dermatology; Surgery; Double blind","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003816771,0.0002104616,0.002480972,0.0002665319,0.00006154522,0.00002070594,0.0001295038,0.0001826917,0.00004139191],"category_scores_gemma":[0.0009813631,0.0001750302,0.0002354606,0.0001492081,0.0003310073,0.0001533438,0.00005840599,0.0004044441,0.000001174186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007673563,"about_ca_system_score_gemma":0.0002744025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001376216,"about_ca_topic_score_gemma":0.000376572,"domain_scores_codex":[0.9962996,0.0004477245,0.002265754,0.0002242526,0.0004524772,0.0003101511],"domain_scores_gemma":[0.9974272,0.0006023228,0.001123858,0.0001861681,0.0004497937,0.0002106974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9814229,0.0007413467,0.009000954,0.0001153545,0.0004049999,0.001741082,0.0008201257,0.000009376572,0.0000984892,0.00000423404,0.0003201441,0.005321014],"study_design_scores_gemma":[0.9367612,0.001938807,0.04804132,0.001382346,0.0002860258,0.01039213,0.00009241592,0.00002819907,0.0006488363,0.000002863359,0.0002731813,0.0001526587],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941091,0.002277104,0.00004492816,0.0008405247,0.0001631413,0.002408205,0.00002242384,0.000006078648,0.0001284958],"genre_scores_gemma":[0.9984119,0.0009483517,0.0003860174,0.0000925299,0.00006803855,0.00001924939,0.00001631574,0.00001843376,0.00003918067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04466166,"threshold_uncertainty_score":0.7137524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0135251132014068,"score_gpt":0.2545675300419585,"score_spread":0.2410424168405517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}