{"id":"W2163901561","doi":"10.1111/j.1365-2133.2008.08487.x","title":"Efficacy and safety of oral alitretinoin (9-cis retinoic acid) in patients with severe chronic hand eczema refractory to topical corticosteroids: results of a randomized, double-blind, placebo-controlled, multicentre trial","year":2008,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Contact Dermatitis and Allergies","field":"Medicine","cited_by":408,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada); Lynde Centre for Dermatology","funders":"","keywords":"Medicine; Placebo; Refractory (planetary science); Adverse effect; Randomized controlled trial; Internal medicine; Placebo-controlled study; Clinical trial; Dermatology; Surgery; Double blind","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003680113,0.001382364,0.003522975,0.0004001178,0.0005487946,0.001069452,0.0008691704,0.002380739,0.00320791],"category_scores_gemma":[0.003152149,0.0007316166,0.002302974,0.0004973657,0.001380886,0.0008413767,0.0003428269,0.001963672,0.0005447351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007613621,"about_ca_system_score_gemma":0.001143517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009250182,"about_ca_topic_score_gemma":0.001607576,"domain_scores_codex":[0.9981451,0.001119722,0.0001756485,0.0002719648,0.0001338274,0.000153755],"domain_scores_gemma":[0.9972197,0.0009597161,0.0007357532,0.0002404329,0.0001976678,0.0006467146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9815326,0.004116659,0.001290723,0.0004789103,0.0009162313,0.00003135422,0.00004430434,0.0001384002,0.002829722,0.00002155589,0.000157325,0.008442196],"study_design_scores_gemma":[0.937229,0.05910002,0.002525271,0.00001960761,0.0005084554,0.00003140844,0.00001060646,0.0001372277,0.0002666629,0.00002113971,0.0001417952,0.000008846562],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920157,0.004994596,0.0002725537,0.0002515287,0.0001479618,0.001376601,0.000309442,0.00003457114,0.0005971213],"genre_scores_gemma":[0.9948284,0.001735505,0.0006944322,0.0003709286,0.0003057928,0.001129224,0.0004066894,0.000008959997,0.000520003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003680113,"threshold_uncertainty_score":0.01946253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0135251132014068,"score_gpt":0.2545675300419585,"score_spread":0.2410424168405517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}