{"id":"W2163903119","doi":"10.2337/db12-1825","title":"Positive Regulation of Insulin Signaling by Neuraminidase 1","year":2013,"lang":"en","type":"article","venue":"Diabetes","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Canada Research Chairs; SickKids Foundation; University of Toronto; Centre Hospitalier Universitaire Sainte-Justine; Alberta Glycomics Centre; Hospital for Sick Children; Institute for Research in Immunology and Cancer; University of Alberta; Université de Montréal","funders":"Canadian Institutes of Health Research; Canadian Diabetes Association","keywords":"Sialidase; Neuraminidase; Insulin receptor; Sialic acid; Phosphorylation; Receptor; Biochemistry; Insulin; Signal transduction; Biology; Protein kinase B; Metabolism; Carbohydrate metabolism; Glycoconjugate; Cell biology; Chemistry; Insulin resistance; Endocrinology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006804811,0.00005144187,0.00006416726,0.00003947328,0.00001439933,0.00001062893,0.00005869962,0.00005830343,0.0001105939],"category_scores_gemma":[0.00008468941,0.00004929335,0.00002384174,0.00008022269,0.00003298786,0.000004509661,0.00002624581,0.00003847644,0.00001844477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004204476,"about_ca_system_score_gemma":0.00001191668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003717642,"about_ca_topic_score_gemma":0.000002139322,"domain_scores_codex":[0.9995139,0.00004042877,0.0001188294,0.0001211701,0.00008276438,0.0001228693],"domain_scores_gemma":[0.9997331,0.00001540454,0.00003462026,0.0001028626,0.0000822646,0.00003177982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005828073,0.000031377,0.01411702,0.000007721217,0.000005608513,7.554506e-8,0.00001393372,0.00003519543,0.9808245,0.00001442752,0.0005549991,0.004389291],"study_design_scores_gemma":[0.0002311973,0.0000972954,0.04358574,0.000009591897,9.844135e-7,7.509731e-8,0.00001682472,0.000676443,0.9548706,0.0001002317,0.0003582104,0.00005280531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988666,0.0002483285,0.00004657838,0.0001046398,0.00001198674,0.0001793145,0.00001173611,0.000002905009,0.0005278899],"genre_scores_gemma":[0.9993145,0.000009132418,0.0001443983,0.00007143411,0.0000191407,0.00002567155,0.0001587042,0.000006531654,0.000250418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02946872,"threshold_uncertainty_score":0.2010125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006835846208070311,"score_gpt":0.2348322644787904,"score_spread":0.2279964182707201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}