{"id":"W2163930982","doi":"10.1074/jbc.c115.698696","title":"Proteolytic Cleavage Driven by Glycosylation","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Deutsche Forschungsgemeinschaft; Canada Council for the Arts","keywords":"Chemistry; Intramolecular force; Adduct; Stereochemistry; Proteolysis; Glycosylation; Proteolytic enzymes; Transferase; Glycosyl; Enzyme; Covalent bond; Active site; Cleavage (geology); Glycosyltransferase; Biochemistry; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002368088,0.0003022533,0.0001806613,0.0001116409,0.00014235,0.0003981787,0.0001768309,0.000349608,0.001161953],"category_scores_gemma":[0.0003408671,0.0001132075,0.0002656496,0.0001170353,0.0001936809,0.0002191679,0.000333024,0.0005904234,0.0004364794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003306463,"about_ca_system_score_gemma":0.0001968276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003315633,"about_ca_topic_score_gemma":0.0002672253,"domain_scores_codex":[0.9997564,0.00003467866,0.00001442765,0.00006318891,0.00005513959,0.00007615898],"domain_scores_gemma":[0.9998595,0.00003049963,0.00004119867,0.0000211552,0.00002102052,0.00002660133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001117408,0.0000174036,0.0005581275,0.00005549435,0.000007645272,0.0002419725,0.00003165271,0.0001011279,0.9945242,0.0007026258,0.0002027804,0.00344521],"study_design_scores_gemma":[0.00001708445,0.0001272161,0.003720332,0.00001144459,0.000008264401,0.0008844881,0.00003974596,0.001988314,0.988277,0.000311821,0.004602481,0.00001187016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841933,0.002059345,0.008839165,0.0001835498,0.0001051304,0.00007993013,0.0003212797,0.00007611907,0.004142189],"genre_scores_gemma":[0.9944533,0.0006814681,0.002602558,0.00007946647,0.00001424065,0.00002546413,0.0003782574,0.00001209121,0.001753158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001161953,"threshold_uncertainty_score":0.003887177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03427555869989923,"score_gpt":0.292215850628577,"score_spread":0.2579402919286778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}