{"id":"W2163955717","doi":"10.1038/ng.536","title":"Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions","year":2010,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":609,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital; Vancouver General Hospital; University of British Columbia","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health; Wellcome Trust","keywords":"Frontotemporal lobar degeneration; Biology; Genetics; Single-nucleotide polymorphism; Genome-wide association study; Frontotemporal dementia; TARDBP; Amyotrophic lateral sclerosis; Linkage disequilibrium; Genetic association; Allele; Haplotype; Dementia; Medicine; Gene; Pathology; Disease; Genotype; Mutant; SOD1","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005916426,0.003538955,0.001630626,0.004779974,0.002229076,0.001122825,0.001999995,0.004469561,0.00773746],"category_scores_gemma":[0.003262586,0.0007254446,0.001747608,0.004045675,0.001601836,0.0008242944,0.001414184,0.001277714,0.001898638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005950139,"about_ca_system_score_gemma":0.000467914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002836247,"about_ca_topic_score_gemma":0.003696339,"domain_scores_codex":[0.9987516,0.0001747125,0.0002356981,0.0003147956,0.0003675594,0.0001556161],"domain_scores_gemma":[0.996518,0.001251833,0.001356026,0.0002005908,0.0002467984,0.0004266849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"observational","study_design_scores_codex":[0.007406941,0.0006441721,0.121485,0.0003741125,0.002079267,0.640905,0.002534335,0.001615014,0.1962743,0.002138509,0.00427055,0.02027295],"study_design_scores_gemma":[0.0006520263,0.000902961,0.3948559,0.0001387566,0.002311673,0.5676439,0.0009029631,0.002824354,0.01942534,0.004634542,0.005448203,0.0002595492],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940985,0.0007072293,0.001171253,0.000345446,0.0001278159,0.00005335308,0.0007936906,0.00009946256,0.002603244],"genre_scores_gemma":[0.9970395,0.0001882234,0.000871246,0.0001123866,0.0001977565,0.00002839633,0.0004126819,0.00004799594,0.001101751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00773746,"threshold_uncertainty_score":0.02588439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01429754072014448,"score_gpt":0.2830952973064609,"score_spread":0.2687977565863164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}