{"id":"W2163955717","doi":"10.1038/ng.536","title":"Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions","year":2010,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":609,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital; Vancouver General Hospital; University of British Columbia","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health; Wellcome Trust","keywords":"Frontotemporal lobar degeneration; Biology; Genetics; Single-nucleotide polymorphism; Genome-wide association study; Frontotemporal dementia; TARDBP; Amyotrophic lateral sclerosis; Linkage disequilibrium; Genetic association; Allele; Haplotype; Dementia; Medicine; Gene; Pathology; Disease; Genotype; Mutant; SOD1","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002229247,0.0002455305,0.0003448896,0.00008327245,0.0003339271,0.00004498954,0.000201826,0.0007511192,0.000280154],"category_scores_gemma":[0.0001356938,0.000160944,0.00004678386,0.0003429211,0.0001447016,0.00006120415,0.0002038577,0.001596854,0.00003104871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002595901,"about_ca_system_score_gemma":0.000227246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005705213,"about_ca_topic_score_gemma":0.007944395,"domain_scores_codex":[0.997901,0.00008493036,0.0002243539,0.0004011559,0.0009510088,0.0004375494],"domain_scores_gemma":[0.998466,0.00004762917,0.0001552931,0.0005657056,0.0004511903,0.0003141564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006972937,0.0003512567,0.8845414,0.00002804698,0.0001907786,0.0002262627,0.0002512368,0.0001298081,0.1049754,0.00004535661,0.007428763,0.001134343],"study_design_scores_gemma":[0.002509555,0.0006309513,0.9858108,0.0001429104,0.0001121273,0.00006448443,0.0000173723,0.001534142,0.006411932,0.00004669444,0.002478673,0.0002403934],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953304,0.0003993137,0.00007745932,0.0023212,0.0002017313,0.0005650322,0.00005531665,0.00007762276,0.0009719296],"genre_scores_gemma":[0.9925256,0.00004941595,0.004311427,0.0008340694,0.0003622639,0.00001837629,0.0003132476,0.00006096639,0.001524658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1012694,"threshold_uncertainty_score":0.6937625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01429754072014448,"score_gpt":0.2830952973064609,"score_spread":0.2687977565863164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}