{"id":"W2163961836","doi":"10.2337/db09-0143","title":"Coexpression of the Type 2 Diabetes Susceptibility Gene Variants <i>KCNJ11</i> E23K and <i>ABCC8</i> S1369A Alter the ATP and Sulfonylurea Sensitivities of the ATP-Sensitive K+ Channel","year":2009,"lang":"en","type":"article","venue":"Diabetes","topic":"Cardiac Ischemia and Reperfusion","field":"Medicine","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Medical Research Council; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale","keywords":"Glibenclamide; Sulfonylurea receptor; Sulfonylurea; Kir6.2; Type 2 diabetes; Internal medicine; Gliclazide; Endocrinology; Biology; Chemistry; Pharmacology; Diabetes mellitus; Medicine; Biochemistry; Protein subunit; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005016682,0.0002350104,0.0005113528,0.00003295041,0.0002142454,0.00001806909,0.0001058185,0.000149986,0.000006267187],"category_scores_gemma":[0.0002564741,0.0001074674,0.0001874942,0.0002235408,0.0006454572,0.00007082333,0.0002321582,0.0002612478,8.746216e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001695887,"about_ca_system_score_gemma":0.00005663158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002546883,"about_ca_topic_score_gemma":0.000002114917,"domain_scores_codex":[0.9985092,0.0002126411,0.0003028924,0.0003191963,0.0003468863,0.0003092225],"domain_scores_gemma":[0.9984664,0.0003985806,0.0001953568,0.0006360631,0.0002296565,0.00007398467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000608739,0.000072371,0.05107795,0.0001015437,0.00007465017,0.000001257528,0.002376833,0.0000041532,0.9444011,0.00001926546,0.0007808179,0.001029214],"study_design_scores_gemma":[0.0005493616,0.0001420002,0.2282066,0.0003503243,0.0002084601,0.000007194406,0.0003702188,0.0001879634,0.7695878,0.0001070056,0.0001765708,0.0001064879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994304,0.001535724,0.000001079814,0.002689225,0.0002959334,0.0005659495,0.00006748184,0.00001962042,0.0005210118],"genre_scores_gemma":[0.9978695,0.000232121,0.00002963341,0.001489246,0.0001709252,0.000004373027,0.00001203648,0.00001845633,0.0001737082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1771287,"threshold_uncertainty_score":0.4382392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007073710456493098,"score_gpt":0.2177707970143421,"score_spread":0.210697086557849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}