{"id":"W2163961836","doi":"10.2337/db09-0143","title":"Coexpression of the Type 2 Diabetes Susceptibility Gene Variants <i>KCNJ11</i> E23K and <i>ABCC8</i> S1369A Alter the ATP and Sulfonylurea Sensitivities of the ATP-Sensitive K+ Channel","year":2009,"lang":"en","type":"article","venue":"Diabetes","topic":"Cardiac Ischemia and Reperfusion","field":"Medicine","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Medical Research Council; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale","keywords":"Glibenclamide; Sulfonylurea receptor; Sulfonylurea; Kir6.2; Type 2 diabetes; Internal medicine; Gliclazide; Endocrinology; Biology; Chemistry; Pharmacology; Diabetes mellitus; Medicine; Biochemistry; Protein subunit; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001724622,0.0004203752,0.0003884412,0.0002070831,0.0001602829,0.0003493253,0.0003136793,0.0003328235,0.003478773],"category_scores_gemma":[0.0003542173,0.0001692863,0.0003413988,0.0003491652,0.0004094375,0.0001259733,0.0002515559,0.0005435129,0.0005460493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002634196,"about_ca_system_score_gemma":0.0001599397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001019339,"about_ca_topic_score_gemma":0.001086793,"domain_scores_codex":[0.9996479,0.00005088376,0.00006308132,0.0001074595,0.0000720105,0.00005873404],"domain_scores_gemma":[0.9995629,0.00008990425,0.0001663949,0.00005418041,0.00002168195,0.0001049687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006645283,0.00009480696,0.003411639,0.00003814555,0.00006979782,0.0005465174,0.0000256082,0.00007530682,0.9934303,0.00008081368,0.0000845274,0.001478153],"study_design_scores_gemma":[0.0003663942,0.002321345,0.1854133,0.00003128478,0.0005061129,0.01179283,0.0002784998,0.002497185,0.7919654,0.0002178151,0.004561491,0.00004832321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983792,0.0002721823,0.0006089997,0.00004418048,0.00004522164,0.00001236214,0.0001996231,0.00001745689,0.0004207159],"genre_scores_gemma":[0.9980789,0.0002251508,0.0007907306,0.00005721152,0.00002075196,0.00001612682,0.00023274,0.00002173282,0.0005567144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003478773,"threshold_uncertainty_score":0.01163763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007073710456493098,"score_gpt":0.2177707970143421,"score_spread":0.210697086557849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}