{"id":"W2163969306","doi":"10.1038/sj.ejhg.5201485","title":"Association of the TSHR gene with Graves' disease: the first disease specific locus","year":2005,"lang":"en","type":"article","venue":"European Journal of Human Genetics","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":177,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Diabetes Research and Wellness Foundation; Alberta Innovates - Health Solutions; Wellcome Trust","keywords":"Locus (genetics); Graves' disease; Gene; Genetics; Disease; Biology; Genome-wide association study; Genetic association; Medicine; Single-nucleotide polymorphism; Internal medicine; Genotype; Thyroid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004131514,0.0001287294,0.0001145641,0.00002310426,0.0001769317,0.00004326241,0.0004659797,0.00002014391,0.00002136762],"category_scores_gemma":[0.0000449513,0.00007457216,0.0001766732,0.00007980108,0.00009649999,0.000003874035,0.00009218999,0.0001308657,0.000005438691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002578513,"about_ca_system_score_gemma":0.00005719997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":3.20343e-7,"about_ca_topic_score_gemma":0.00001284781,"domain_scores_codex":[0.9988366,0.0002004425,0.0003318132,0.0001238948,0.0003217008,0.0001855628],"domain_scores_gemma":[0.998768,0.00001154179,0.0005821773,0.0003316185,0.00019221,0.0001143919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000760385,0.001464008,0.5989159,0.00009750718,0.001857634,0.00009053473,0.001045626,0.03381938,0.1478237,0.0002638386,0.1900151,0.02384643],"study_design_scores_gemma":[0.001753756,0.0004906409,0.5479761,0.00008054193,0.0003146525,0.000004540313,0.0001082768,0.0000272147,0.01483786,0.00009130591,0.4340406,0.0002745507],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897656,0.00706862,0.0000924231,0.002000904,0.0001183221,0.0001030573,0.00002653304,0.000002656544,0.0008218974],"genre_scores_gemma":[0.9971893,0.0008720905,0.0000931635,0.0003475157,0.0006028916,5.636928e-7,0.000009806129,0.00003218442,0.0008524614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2440255,"threshold_uncertainty_score":0.3040964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006528587252920419,"score_gpt":0.1965792255445103,"score_spread":0.1900506382915899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}