{"id":"W2163970712","doi":"10.1128/aac.00870-06","title":"Natural Polymorphisms in the Human Immunodeficiency Virus Type 2 Protease Can Accelerate Time to Development of Resistance to Protease Inhibitors","year":2006,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; Canadian Foundation for AIDS Research; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Nelfinavir; Amprenavir; Indinavir; Biology; Virology; Protease; Protease inhibitor (pharmacology); Drug resistance; Virus; Genotype; Wild type; Lentivirus; Context (archaeology); Resistance mutation; Genetics; Mutant; Gene; HIV-1 protease; Viral load; Viral disease; Reverse transcriptase; Sida; Polymerase chain reaction; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001769348,0.0001390599,0.000149321,0.0001169928,0.0001055108,0.0002983283,0.000119954,0.0002509826,0.001093561],"category_scores_gemma":[0.0005438399,0.00009237805,0.0001619462,0.00009376691,0.00008237909,0.0002100497,0.0001349834,0.0003712927,0.0001446403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001507245,"about_ca_system_score_gemma":0.0001090601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003533013,"about_ca_topic_score_gemma":0.0005607051,"domain_scores_codex":[0.9999117,0.00001832923,0.00000948117,0.00001749945,0.0000209552,0.00002194257],"domain_scores_gemma":[0.9997285,0.00009970233,0.00007832319,0.00001840909,0.00002899741,0.00004610015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009792292,0.0002801762,0.03866454,0.00005345951,0.00004037295,0.0009623869,0.0001161702,0.0003989205,0.9466267,0.0002177248,0.000127257,0.01153305],"study_design_scores_gemma":[0.0000856069,0.0064031,0.4396196,0.00003053098,0.000103174,0.006785025,0.0002449511,0.003166356,0.5381282,0.0002981647,0.005091853,0.00004347176],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986758,0.0005049604,0.0003548923,0.00002059296,0.000005250962,0.00001076135,0.00007047371,0.00001086463,0.0003464523],"genre_scores_gemma":[0.9987907,0.0002454117,0.0003759405,0.00002372883,0.000004265622,0.00001057134,0.0001535194,0.000003739074,0.0003921406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001093561,"threshold_uncertainty_score":0.003658354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01054736200651564,"score_gpt":0.2482197212022962,"score_spread":0.2376723591957805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}