{"id":"W2163970712","doi":"10.1128/aac.00870-06","title":"Natural Polymorphisms in the Human Immunodeficiency Virus Type 2 Protease Can Accelerate Time to Development of Resistance to Protease Inhibitors","year":2006,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; Canadian Foundation for AIDS Research; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Nelfinavir; Amprenavir; Indinavir; Biology; Virology; Protease; Protease inhibitor (pharmacology); Drug resistance; Virus; Genotype; Wild type; Lentivirus; Context (archaeology); Resistance mutation; Genetics; Mutant; Gene; HIV-1 protease; Viral load; Viral disease; Reverse transcriptase; Sida; Polymerase chain reaction; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001700553,0.0002196759,0.0002738317,0.0001480804,0.0001664789,0.00003659419,0.000132797,0.00004931414,0.0001137255],"category_scores_gemma":[0.000005984766,0.0001510969,0.00004327154,0.0004187017,0.00004159254,0.00003892489,0.00003442169,0.00009901306,0.00004618821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008732739,"about_ca_system_score_gemma":0.0001335767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001681951,"about_ca_topic_score_gemma":0.0001240149,"domain_scores_codex":[0.9987785,0.00002992487,0.0003848062,0.0002973564,0.0002171324,0.0002923158],"domain_scores_gemma":[0.9995822,0.000006888365,0.00008051655,0.0001960945,0.00006476613,0.0000695809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008667889,0.00145184,0.02058998,0.00008164664,0.00008726701,0.0000777692,0.008466549,0.000002911355,0.9012751,0.00002247977,0.06225583,0.004821841],"study_design_scores_gemma":[0.003702095,0.0001639529,0.2159538,0.0004936039,0.00003339046,0.00001365632,0.00009723069,0.000004652714,0.6903737,0.00001940291,0.08867493,0.0004696071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989038,0.00004808376,0.000004230666,0.00876906,0.00003439363,0.001597151,0.000009373457,0.00001893613,0.0004807536],"genre_scores_gemma":[0.98197,0.000008709682,0.001584257,0.003360239,0.00004577094,0.00005536883,0.00005724153,0.00002414467,0.01289428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2109014,"threshold_uncertainty_score":0.6161554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01054736200651564,"score_gpt":0.2482197212022962,"score_spread":0.2376723591957805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}