{"id":"W2163971374","doi":"10.1016/j.stem.2011.10.012","title":"Forward and Reverse Genetics through Derivation of Haploid Mouse Embryonic Stem Cells","year":2011,"lang":"en","type":"article","venue":"Cell stem cell","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":240,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Ottawa Hospital","funders":"Canadian Institutes of Health Research; National Human Genome Research Institute; Howard Hughes Medical Institute","keywords":"Biology; Genetics; Somatic cell; Germline; Embryonic stem cell; Ploidy; Stem cell; Mutagenesis; Genome; Cell biology; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008096863,0.0001720105,0.0001634912,0.00002640906,0.00003705069,0.000009022233,0.0001432706,0.0001527455,0.00001670229],"category_scores_gemma":[8.338909e-7,0.0001778518,0.00007034008,0.00005701591,0.0000485114,0.000004384056,0.0001078635,0.00006429233,0.0000102499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008194243,"about_ca_system_score_gemma":0.00003153394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001642048,"about_ca_topic_score_gemma":0.000006519873,"domain_scores_codex":[0.9991396,0.00002441909,0.0002289593,0.0002959377,0.00009365308,0.0002174476],"domain_scores_gemma":[0.9993963,0.000007448553,0.0001010275,0.0003666886,0.00005677632,0.00007179433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002276376,0.00005090337,0.0005908165,0.0001988747,0.0000147183,0.000001379118,0.0004494666,0.0002167072,0.9970306,0.00001051288,0.0006932129,0.0007200345],"study_design_scores_gemma":[0.0004301388,0.0002238653,0.0001747426,0.000009075841,0.00003371774,0.000002600574,0.0003990348,0.0001167191,0.9872363,0.00001199283,0.01116682,0.0001949726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777575,0.0036754,0.01500397,0.000005318258,0.0001458272,0.0002064198,0.00001484863,0.0000140338,0.003176648],"genre_scores_gemma":[0.9900489,0.001749181,0.003895496,0.00004436686,0.00005057034,0.000008056944,0.000013063,0.00003685269,0.004153449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01229143,"threshold_uncertainty_score":0.7252585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01449007486466034,"score_gpt":0.2299372506512334,"score_spread":0.2154471757865731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}