{"id":"W2163981419","doi":"10.1534/genetics.108.089383","title":"Direct Evidence That Genetic Variation in Glycerol-3-Phosphate and Malate Dehydrogenase Genes (<i>Gpdh</i> and <i>Mdh1</i>) Affects Adult Ethanol Tolerance in <i>Drosophila melanogaster</i>","year":2008,"lang":"en","type":"article","venue":"Genetics","topic":"Physiological and biochemical adaptations","field":"Environmental Science","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Laurentian University","funders":"National Institute of General Medical Sciences; Exelixis; National Science Foundation","keywords":"Alcohol dehydrogenase; Biology; Malate dehydrogenase; Drosophila melanogaster; Allele; Genetics; Dehydrogenase; Biochemistry; Enzyme; Ethanol; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009175113,0.0002079757,0.0002220477,0.00003053412,0.0000884247,0.00002099509,0.0001525577,0.0001165001,0.00002730177],"category_scores_gemma":[0.00004747388,0.0001799257,0.00002857467,0.0002788095,0.0002387573,0.0001337063,0.0002052385,0.0001254867,0.00002490028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004471752,"about_ca_system_score_gemma":0.00000978871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001136348,"about_ca_topic_score_gemma":0.00026537,"domain_scores_codex":[0.9986028,0.00009095386,0.0002239176,0.0005182466,0.0002204483,0.0003436288],"domain_scores_gemma":[0.9994477,0.0001297426,0.00009486113,0.0001837318,0.000008556367,0.0001354157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00006245528,0.00006675374,0.1913176,0.0000192706,0.000003388781,0.00004275276,0.0002851642,0.003324763,0.8020084,0.00000297765,0.00002635032,0.002840064],"study_design_scores_gemma":[0.0005268084,0.0001206589,0.7972685,0.00007113843,0.000009899731,0.00003363425,0.000005401344,0.006375279,0.1947199,0.0005218752,0.00009486958,0.000252038],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954832,0.003666973,0.00007128063,0.0002911239,0.00004071029,0.0003007154,0.000009507019,0.00002274908,0.0001137919],"genre_scores_gemma":[0.986819,0.009755437,0.002672861,0.0006310302,0.00002721339,0.00004464602,0.00000293938,0.00001216596,0.00003473829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6072885,"threshold_uncertainty_score":0.7337159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01903312277847084,"score_gpt":0.2122935526969182,"score_spread":0.1932604299184474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}