{"id":"W2164018421","doi":"10.1002/anie.201302406","title":"LovG: The Thioesterase Required for Dihydromonacolin L Release and Lovastatin Nonaketide Synthase Turnover in Lovastatin Biosynthesis","year":2013,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences","keywords":"Lovastatin; Thioesterase; Biosynthesis; ATP synthase; Chemistry; Biochemistry; Hydrolysis; Enzyme; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002588276,0.0002147935,0.000149266,0.0000556327,0.00007793342,0.00008725392,0.0002382299,0.0001629896,0.0001479709],"category_scores_gemma":[0.0005144233,0.0001699339,0.0000976654,0.00007466227,0.0001276961,0.00003577035,0.00006615765,0.0001055007,0.00001476111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003953681,"about_ca_system_score_gemma":0.00003993879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009221726,"about_ca_topic_score_gemma":0.00007655627,"domain_scores_codex":[0.9987742,0.0000369651,0.0003138859,0.0004247279,0.0002013378,0.0002489307],"domain_scores_gemma":[0.9991933,0.0002222621,0.0001437151,0.0002180766,0.0001346694,0.0000879366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002456225,0.0001171367,0.0003735755,0.00003344617,0.00006354834,0.000007591174,0.00007275923,0.000009404206,0.9758086,0.00001809566,0.02086399,0.002386214],"study_design_scores_gemma":[0.000698198,0.00005646424,0.001844787,0.0000847972,0.00002235904,0.00004161141,0.0001283044,0.0002448682,0.9850809,0.0002473603,0.01132267,0.0002276954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937807,0.0001712445,0.0009383372,0.002922677,0.0002393136,0.0004194497,0.0007259116,0.0000150827,0.0007872806],"genre_scores_gemma":[0.9955601,0.0001891305,0.0005355474,0.0006653686,0.0007706828,0.0002104753,0.001288452,0.00002182643,0.0007584249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009541324,"threshold_uncertainty_score":0.6929703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01077574452578258,"score_gpt":0.2385448562975281,"score_spread":0.2277691117717455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}