{"id":"W2164056348","doi":"10.1148/radiol.11101893","title":"Dynamic Microbubble Contrast-enhanced US to Measure Tumor Response to Targeted Therapy: A Proposed Clinical Protocol with Results from Renal Cell Carcinoma Patients Receiving Antiangiogenic Therapy","year":2011,"lang":"en","type":"article","venue":"Radiology","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":135,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Renal cell carcinoma; Interquartile range; Response Evaluation Criteria in Solid Tumors; Sunitinib; Bolus (digestion); Nuclear medicine; Institutional review board; Reproducibility; Radiology; Urology; Progressive disease; Internal medicine; Surgery; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004156349,0.0003215545,0.0004739801,0.0001303536,0.0001067986,0.0000218271,0.0003776084,0.0001836492,0.00006967947],"category_scores_gemma":[0.00009052629,0.0002536166,0.0001127021,0.0003157969,0.00007367942,0.0000600097,0.0000203138,0.0002606782,0.00009413647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009360479,"about_ca_system_score_gemma":0.0001243657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001003909,"about_ca_topic_score_gemma":0.0001597475,"domain_scores_codex":[0.9978069,0.0003596001,0.0005941245,0.0005987663,0.0001327201,0.0005078602],"domain_scores_gemma":[0.9986346,0.0002602799,0.0001117913,0.0005987001,0.0001509631,0.0002437026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01743641,0.0003112946,0.01198221,0.000006108264,0.0001342274,0.00001136806,0.002327866,0.0002623966,0.9631565,0.000001000959,0.0005683406,0.003802235],"study_design_scores_gemma":[0.01273,0.003163647,0.7672961,0.00004845119,0.0000268295,0.00001531427,0.00005812079,0.0003569002,0.2084934,0.00002582235,0.007109439,0.0006759625],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9704126,0.00006236087,0.002700548,0.00006534599,0.0001139343,0.02596536,0.0001671445,0.0002331841,0.0002795577],"genre_scores_gemma":[0.9783853,0.000007003397,0.008787565,0.0003268907,0.0000712074,0.01222079,0.00006308872,0.00008772659,0.00005038948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7553139,"threshold_uncertainty_score":0.9999916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01844282441612198,"score_gpt":0.2389620423415199,"score_spread":0.2205192179253979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}