{"id":"W2164076798","doi":"10.1074/mcp.m700312-mcp200","title":"Defining the Specificity Space of the Human Src Homology 2 Domain","year":2007,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":228,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Western University","funders":"","keywords":"Proto-oncogene tyrosine-protein kinase Src; Homology (biology); Computational biology; Domain (mathematical analysis); Biology; Genetics; Mathematics; Gene; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009919766,0.0002076986,0.0002124899,0.00005605789,0.0004845151,0.00003429267,0.000883029,0.0001150462,0.00002966849],"category_scores_gemma":[0.0002462287,0.0001384633,0.0002120937,0.0004185282,0.0004778511,0.00004634688,0.0003019305,0.0005046676,0.00002854102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004683695,"about_ca_system_score_gemma":0.00005385423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003325256,"about_ca_topic_score_gemma":0.000009038959,"domain_scores_codex":[0.9978549,0.0003604882,0.0004103824,0.0004337833,0.0004582512,0.000482127],"domain_scores_gemma":[0.9987003,0.0001744468,0.0003022144,0.0007192593,0.00004085806,0.00006288749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002031109,0.0000399277,0.00033335,0.000009822864,0.000004399797,0.000103388,0.0001737155,0.0001615472,0.8972777,0.1017638,0.00002220945,0.00008981803],"study_design_scores_gemma":[0.0002391948,0.00005978076,0.0003601589,0.00002009021,0.00001345032,0.00004486016,0.00006903018,0.00004962847,0.9897954,0.007461607,0.001733881,0.0001528972],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.959883,0.0002425439,0.03489934,0.0005787197,0.000187106,0.0006384062,0.000004858939,0.00003322609,0.003532768],"genre_scores_gemma":[0.9975092,0.000006554385,0.001318075,0.0009028632,0.00006173895,0.00001336513,0.000001050084,0.00003819704,0.0001489946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09430224,"threshold_uncertainty_score":0.564637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01501006037846354,"score_gpt":0.246265959755987,"score_spread":0.2312558993775235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}