{"id":"W2164107048","doi":"10.1039/c4nj02346c","title":"Tris-hydroxymethylaminomethane (THAM): a novel organocatalyst for a environmentally benign synthesis of medicinally important tetrahydrobenzo[b]pyrans and pyran-annulated heterocycles","year":2015,"lang":"en","type":"article","venue":"New Journal of Chemistry","topic":"Multicomponent Synthesis of Heterocycles","field":"Chemistry","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Society of Intestinal Research","funders":"","keywords":"Chemistry; Pyran; Tris; Catalysis; Organic chemistry; Combinatorial chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000922885,0.0002657348,0.0001075828,0.0001938054,0.0001197971,0.0001174084,0.0002697534,0.0002016974,0.0009376759],"category_scores_gemma":[0.00008081151,0.0001225704,0.0001140206,0.0001170001,0.000146419,0.0002610775,0.000252098,0.0002745198,0.0003260395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002154653,"about_ca_system_score_gemma":0.0002849048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004024691,"about_ca_topic_score_gemma":0.00111538,"domain_scores_codex":[0.9999424,0.000005232147,0.000004636469,0.00001490113,0.00002047642,0.00001228321],"domain_scores_gemma":[0.9999619,0.000005396546,0.00001486438,0.000004086586,0.000005408582,0.000008361173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003357702,0.00001032939,0.00006415952,0.00006391219,0.000004322447,0.00006191758,0.00001650676,0.0001077128,0.9954988,0.0004517696,0.00007046605,0.003616398],"study_design_scores_gemma":[0.000006090282,0.0001253033,0.0002365512,0.000002914871,0.000006630195,0.0001655749,0.000006681132,0.0004821489,0.996539,0.00003937474,0.002385966,0.000003801962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9578034,0.004180466,0.02821607,0.0001667914,0.00008570166,0.0001030124,0.0002799804,0.0003871357,0.008777377],"genre_scores_gemma":[0.9828395,0.001384234,0.01243611,0.00003209227,0.00001523632,0.00003123539,0.0001466621,0.00003310287,0.003081733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009376759,"threshold_uncertainty_score":0.003136814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02222176960477608,"score_gpt":0.2436327862484,"score_spread":0.2214110166436239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}