{"id":"W2164137922","doi":"10.1091/mbc.e14-12-1612","title":"Dendritic and axonal mechanisms of Ca<sup>2+</sup> elevation impair BDNF transport in Aβ oligomer–treated hippocampal neurons","year":2015,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia","funders":"Canadian Institutes of Health Research; Simon Fraser University","keywords":"Axoplasmic transport; Biology; Neuroscience; Hippocampal formation; Dendritic spine; Cell biology; Intracellular; Axon; Endocrinology; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001106297,0.0002956889,0.0005120128,0.0002107566,0.0002614517,0.0003737493,0.0003682728,0.0003898623,0.001308815],"category_scores_gemma":[0.00009964361,0.0001481958,0.0003460093,0.0002366395,0.0002343183,0.0003609142,0.0002423892,0.000864182,0.0005165071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003722113,"about_ca_system_score_gemma":0.0004113786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002164306,"about_ca_topic_score_gemma":0.004019669,"domain_scores_codex":[0.9998279,0.00001285842,0.00002603797,0.00003409849,0.0000477136,0.00005147236],"domain_scores_gemma":[0.9999173,0.000008284905,0.00001986869,0.00001473643,0.00001666012,0.00002310742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003780643,0.0001017117,0.0001404529,0.00005002489,0.000009192816,0.00009967261,0.00002613263,0.00004442162,0.9975622,0.00008349835,0.00006487385,0.00143983],"study_design_scores_gemma":[0.0000714058,0.0005976589,0.007700613,0.00001516813,0.00002522827,0.0002650822,0.00006670997,0.0007322628,0.9889976,0.0001253592,0.00139669,0.000006114513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928786,0.001688736,0.001640255,0.0001391679,0.00005725362,0.0000531984,0.0007483815,0.0001066496,0.002687732],"genre_scores_gemma":[0.9910508,0.001753099,0.002614218,0.00009755407,0.00001391567,0.0001111333,0.0006501177,0.00002776004,0.003681457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002164306,"threshold_uncertainty_score":0.004378498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01696216074430282,"score_gpt":0.2735378709617847,"score_spread":0.2565757102174818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}