{"id":"W2164180770","doi":"10.1093/carcin/bgq276","title":"Estrogen receptor alpha pathway is involved in leptin-induced ovarian cancer cell growth","year":2010,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Leptin; Endocrinology; Internal medicine; Protein kinase B; PI3K/AKT/mTOR pathway; Estrogen receptor; Transactivation; Cell growth; Leptin receptor; Transfection; Biology; Chemistry; Signal transduction; Small interfering RNA; Cancer research; Cell biology; Cell culture; Gene expression; Medicine; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001358252,0.0003743569,0.0002585876,0.0003461681,0.000256956,0.0002906094,0.0001135815,0.0002381241,0.001797867],"category_scores_gemma":[0.0001090687,0.0001444876,0.000372645,0.0002768771,0.0001408576,0.0001868027,0.0002150144,0.0004373761,0.0004225739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000256918,"about_ca_system_score_gemma":0.0002918324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007940934,"about_ca_topic_score_gemma":0.001158523,"domain_scores_codex":[0.9998748,0.00002416878,0.00001441734,0.00001684248,0.00003271418,0.00003711088],"domain_scores_gemma":[0.9999447,0.000007096658,0.00001625228,0.000006432401,0.00001021095,0.00001530945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009976596,0.000156394,0.001906746,0.0004017803,0.00003169871,0.0008193367,0.00005965416,0.0001727807,0.9854426,0.0006718128,0.0004196563,0.008919858],"study_design_scores_gemma":[0.0002857609,0.001402315,0.06729139,0.00007950361,0.00009969485,0.002796634,0.0001902235,0.003173475,0.8853754,0.0009022751,0.03837818,0.00002516662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9162788,0.06645665,0.005403133,0.0008694935,0.000235865,0.0001843827,0.002310578,0.0002381776,0.008022837],"genre_scores_gemma":[0.9733813,0.0162604,0.00210639,0.000191449,0.00003332769,0.0001390642,0.001915727,0.00001724879,0.005955121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001797867,"threshold_uncertainty_score":0.006014407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03098900670465705,"score_gpt":0.2521910858011325,"score_spread":0.2212020790964755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}