{"id":"W2164180770","doi":"10.1093/carcin/bgq276","title":"Estrogen receptor alpha pathway is involved in leptin-induced ovarian cancer cell growth","year":2010,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Leptin; Endocrinology; Internal medicine; Protein kinase B; PI3K/AKT/mTOR pathway; Estrogen receptor; Transactivation; Cell growth; Leptin receptor; Transfection; Biology; Chemistry; Signal transduction; Small interfering RNA; Cancer research; Cell biology; Cell culture; Gene expression; Medicine; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001961328,0.0002377255,0.0002497038,0.0001177144,0.0001636384,0.00006124814,0.0004356905,0.0001994149,0.001346425],"category_scores_gemma":[0.0001105596,0.0002335423,0.0001286419,0.0004540565,0.00007572139,0.0002603776,0.0001010328,0.000220163,0.0002255606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008521597,"about_ca_system_score_gemma":0.0001856631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001520117,"about_ca_topic_score_gemma":0.0007515914,"domain_scores_codex":[0.998158,0.0001043121,0.0003106265,0.00065146,0.0003390335,0.0004365924],"domain_scores_gemma":[0.9990003,0.00009522567,0.0001268825,0.0004904498,0.00008684024,0.0002002649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002216498,0.00007120993,0.1058684,0.00001759934,0.000002081697,0.000009265452,0.0003386164,0.000001911514,0.8908355,0.0009913814,0.0003410235,0.001500925],"study_design_scores_gemma":[0.0005111887,0.00003135556,0.08348037,0.00001001,0.000007978108,0.000001718853,0.00005228056,0.0000950191,0.9106571,0.0001216721,0.004780155,0.0002511154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951776,0.0001035806,0.00000814839,0.0007574137,0.0007020299,0.0002899319,0.00004760929,0.0000792127,0.002834508],"genre_scores_gemma":[0.9974315,0.0001133931,0.000279277,0.001158535,0.0002742676,0.00005694272,0.000005642472,0.00004038682,0.0006401115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.022388,"threshold_uncertainty_score":0.9995665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03098900670465705,"score_gpt":0.2521910858011325,"score_spread":0.2212020790964755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}