{"id":"W2164187183","doi":"10.1002/ardp.200600072","title":"Synthesis of 4′‐Hydroxy‐3′‐piperidinomethylchalcone Derivatives and Their Cytotoxicity Against PC‐3 Cell Lines","year":2007,"lang":"en","type":"article","venue":"Archiv der Pharmazie","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Cytotoxicity; Chalcone; Chemistry; Stereochemistry; Aryl; Chemical synthesis; Cell culture; In vitro; Mannich base; Potency; Cytotoxic T cell; Biochemistry; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001216519,0.0004192207,0.0002323607,0.0002463401,0.000105586,0.0001385582,0.0002260836,0.0001717061,0.001347922],"category_scores_gemma":[0.0001420878,0.0001285556,0.0001674047,0.0002480477,0.0001208481,0.0001957951,0.0001374309,0.0003210206,0.000414401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001785328,"about_ca_system_score_gemma":0.0002523419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006059189,"about_ca_topic_score_gemma":0.001506884,"domain_scores_codex":[0.99994,0.00001186156,0.000007611375,0.00001040379,0.00001573382,0.0000143675],"domain_scores_gemma":[0.9998721,0.00001719116,0.00003627151,0.00001353326,0.00002528294,0.00003570992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001431577,0.0000337879,0.0001131224,0.0001179841,0.000006639515,0.0001187391,0.00002252842,0.0003931187,0.9911894,0.0001162497,0.00006168341,0.007683628],"study_design_scores_gemma":[0.00003788742,0.001079819,0.001751463,0.000008305668,0.00002165491,0.0002570538,0.00001114451,0.0002099077,0.9894547,0.00003506852,0.007122419,0.00001059646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.970215,0.01285034,0.009641751,0.0001264996,0.00007482653,0.0002173212,0.001194326,0.0001996832,0.005480206],"genre_scores_gemma":[0.9750351,0.007916069,0.01071903,0.00008148213,0.00003283647,0.000173156,0.001234014,0.0000256906,0.00478252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001347922,"threshold_uncertainty_score":0.00450927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02464371902838337,"score_gpt":0.2530283499400096,"score_spread":0.2283846309116262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}