{"id":"W2164189282","doi":"10.1124/dmd.114.062315","title":"Polyinosinic/Polycytidylic Acid–Mediated Changes in Maternal and Fetal Disposition of Lopinavir in Rats","year":2015,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Lopinavir; Placenta; Pharmacokinetics; Pharmacology; Gestation; Fetus; Transporter; Chemistry; Endocrinology; Fetal membrane; Internal medicine; Andrology; Medicine; Pregnancy; Biology; Immunology; Biochemistry; Viral load; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002189237,0.0001814258,0.0003926714,0.0003434909,0.0000283146,0.00002041893,0.00003236344,0.00007806131,0.00001101155],"category_scores_gemma":[0.00001833802,0.0001522592,0.0000276554,0.0002494035,0.00007682123,0.000196054,0.00003822608,0.00009926382,0.000007605606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005543094,"about_ca_system_score_gemma":0.00005292559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002491083,"about_ca_topic_score_gemma":0.0003021909,"domain_scores_codex":[0.9989499,0.00007663908,0.0002845969,0.0002514054,0.0002213414,0.0002161393],"domain_scores_gemma":[0.9995781,0.00002311222,0.00008492456,0.0001062742,0.00003866347,0.0001689588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003194312,0.001115747,0.8503617,0.0004138131,0.0001316075,0.0003654458,0.01181802,0.000002245592,0.08792873,0.001791323,0.0003323104,0.04254474],"study_design_scores_gemma":[0.005544207,0.00007155947,0.9360627,0.0003227968,0.0001160365,0.0000568527,0.0005075976,0.0002029205,0.05640814,0.0002350916,0.0002933526,0.0001787486],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929496,0.004563123,0.00001784349,0.001629967,0.0001157352,0.000375165,0.00004012898,0.00002074982,0.000287706],"genre_scores_gemma":[0.998033,0.0008549711,0.0002864353,0.0001092552,0.00006540819,0.00004542937,0.0002894666,0.00001419839,0.0003018352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.085701,"threshold_uncertainty_score":0.620895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01267987180432338,"score_gpt":0.2529457977434164,"score_spread":0.240265925939093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}