{"id":"W2164189282","doi":"10.1124/dmd.114.062315","title":"Polyinosinic/Polycytidylic Acid–Mediated Changes in Maternal and Fetal Disposition of Lopinavir in Rats","year":2015,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Lopinavir; Placenta; Pharmacokinetics; Pharmacology; Gestation; Fetus; Transporter; Chemistry; Endocrinology; Fetal membrane; Internal medicine; Andrology; Medicine; Pregnancy; Biology; Immunology; Biochemistry; Viral load; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002813522,0.000788893,0.0005379426,0.001172506,0.0005128769,0.0005305288,0.0004822407,0.0006807795,0.002259388],"category_scores_gemma":[0.0004735606,0.0006294828,0.0005117072,0.0003432128,0.001200286,0.001072529,0.0002922339,0.001934298,0.0004729177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001475796,"about_ca_system_score_gemma":0.001343479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005826983,"about_ca_topic_score_gemma":0.006826499,"domain_scores_codex":[0.9997156,0.00005346612,0.00001526659,0.0000896782,0.00003903061,0.00008681355],"domain_scores_gemma":[0.9993037,0.0001309048,0.0001865868,0.0001215131,0.0000635059,0.0001938537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.04325304,0.001687455,0.00681856,0.0001497227,0.0001095856,0.001916933,0.0004136267,0.0006221471,0.9186295,0.001753399,0.0005184817,0.02412748],"study_design_scores_gemma":[0.0002920706,0.005957779,0.02300602,0.00002155006,0.0002203439,0.000622138,0.0005098591,0.002540463,0.9641623,0.0004708512,0.002117187,0.00007956981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947993,0.001115802,0.001720724,0.0002432506,0.00008836803,0.00002042522,0.0005590563,0.0001567394,0.00129638],"genre_scores_gemma":[0.9909088,0.001304304,0.00160304,0.0001579719,0.0000307132,0.00006775257,0.0005610692,0.0000600392,0.005306292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005826983,"threshold_uncertainty_score":0.01158613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01267987180432338,"score_gpt":0.2529457977434164,"score_spread":0.240265925939093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}