{"id":"W2164215375","doi":"10.1001/jamaneurol.2015.0607","title":"Targeting Prodromal Alzheimer Disease With Avagacestat","year":2015,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":233,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Bristol-Myers Squibb","keywords":"Medicine; Biomarker; Tolerability; Population; Discontinuation; Internal medicine; Placebo; Cohort; Randomized controlled trial; Dementia; Clinical trial; Adverse effect; Oncology; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001369981,0.0006031501,0.0009995901,0.0003174476,0.000205326,0.0005676732,0.0004885761,0.0008384938,0.002854071],"category_scores_gemma":[0.001215619,0.0001836068,0.0007565767,0.0003277342,0.0005323924,0.0004267903,0.000192061,0.001108938,0.0003738446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002226495,"about_ca_system_score_gemma":0.0004655358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002269988,"about_ca_topic_score_gemma":0.0008163369,"domain_scores_codex":[0.9996253,0.0001686173,0.00005790018,0.00006268034,0.00005485418,0.00003058515],"domain_scores_gemma":[0.9992648,0.0002670121,0.0002470507,0.00004457967,0.00005592146,0.0001206512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6842038,0.01100211,0.01999956,0.003191975,0.002551913,0.0005121783,0.0001669605,0.0009243464,0.04087215,0.0004599637,0.001878591,0.2342365],"study_design_scores_gemma":[0.5938463,0.3270722,0.0503064,0.0003709122,0.002762861,0.001100406,0.0001253468,0.001640557,0.01450995,0.0008002251,0.007408633,0.00005625909],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808772,0.01497496,0.000690277,0.0004249695,0.0002118019,0.0008365773,0.0003726307,0.00005969689,0.001551931],"genre_scores_gemma":[0.9913707,0.005053348,0.001168685,0.0003803807,0.000302965,0.0004770023,0.0003537662,0.000007929371,0.0008852428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002854071,"threshold_uncertainty_score":0.00954783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03234066026229249,"score_gpt":0.3056843094859016,"score_spread":0.2733436492236091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}