{"id":"W2164215375","doi":"10.1001/jamaneurol.2015.0607","title":"Targeting Prodromal Alzheimer Disease With Avagacestat","year":2015,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":233,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Bristol-Myers Squibb","keywords":"Medicine; Biomarker; Tolerability; Population; Discontinuation; Internal medicine; Placebo; Cohort; Randomized controlled trial; Dementia; Clinical trial; Adverse effect; Oncology; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002392505,0.0001134853,0.0001541985,0.0000834583,0.00004178452,0.00002422451,0.00007238026,0.00005746158,0.0001827144],"category_scores_gemma":[0.0002201493,0.00008098641,0.0000285941,0.000130212,0.0001321314,0.0001058795,0.00006919257,0.0003407612,0.000223955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007037639,"about_ca_system_score_gemma":0.0002284718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001301735,"about_ca_topic_score_gemma":0.000001311045,"domain_scores_codex":[0.9987212,0.0001292207,0.0001227576,0.0002997429,0.0003482563,0.0003788569],"domain_scores_gemma":[0.9990629,0.00004539035,0.00003713735,0.0001700605,0.0002023474,0.0004821889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006710342,0.0003554167,0.9677946,0.00002619978,0.00009297716,0.003928249,0.0001210888,0.00001116925,0.0006400855,0.00009152044,0.01466213,0.005566215],"study_design_scores_gemma":[0.006287323,0.005959738,0.9200729,0.00001665673,0.0003096408,0.0003590808,0.00007845028,0.001109492,0.0007675605,0.000180214,0.06467484,0.0001841347],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97368,0.0002963891,0.00008626888,0.01556175,0.00008530361,0.0004833812,0.000003344495,0.00007043294,0.009733175],"genre_scores_gemma":[0.9939676,0.00001020981,0.0001610631,0.004782496,0.0002449325,0.00006061726,0.00003012937,0.00002276666,0.0007201995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05001272,"threshold_uncertainty_score":0.330253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03234066026229249,"score_gpt":0.3056843094859016,"score_spread":0.2733436492236091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}