{"id":"W2164235117","doi":"10.4049/jimmunol.0803979","title":"Infection with Arginase-Deficient <i>Leishmania major</i> Reveals a Parasite Number-Dependent and Cytokine-Independent Regulation of Host Cellular Arginase Activity and Disease Pathogenesis","year":2009,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Arginase; Biology; Infectivity; Immune system; Cytokine; In vivo; Leishmania; In vitro; Pathogenesis; Leishmania major; Immunology; Arginine; Microbiology; Parasite hosting; Biochemistry; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001095116,0.0003111766,0.0002074194,0.0001619341,0.00007563193,0.0003235435,0.0001683138,0.0002925405,0.0006651164],"category_scores_gemma":[0.00009915168,0.0001746421,0.0002553302,0.00008914806,0.0002329264,0.0002177326,0.0001292693,0.0005915558,0.000398364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002488445,"about_ca_system_score_gemma":0.000102633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002783832,"about_ca_topic_score_gemma":0.0003140449,"domain_scores_codex":[0.9998521,0.0000266251,0.00001850664,0.00003421284,0.00002185064,0.00004679004],"domain_scores_gemma":[0.9998403,0.00001976185,0.0000680844,0.00001624117,0.00001156648,0.00004414453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001062661,0.00001597464,0.0001308532,0.000008607087,0.000001357455,0.0000279559,0.000004846804,0.00001221855,0.9995159,0.00002333234,0.000008403864,0.0001444053],"study_design_scores_gemma":[0.000021862,0.0006526201,0.009685635,0.000005026357,0.00001826959,0.0009382845,0.00004307613,0.000927953,0.9868166,0.00005165523,0.0008315159,0.000007500672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977432,0.0003759641,0.001087487,0.00005148539,0.000009347554,0.00001281256,0.0002287981,0.00003994103,0.0004509272],"genre_scores_gemma":[0.9966115,0.0002618387,0.001329377,0.00005343412,0.000009191064,0.00002391101,0.0005858192,0.00002403488,0.00110095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006651164,"threshold_uncertainty_score":0.002225101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01182243450253742,"score_gpt":0.2628309660810717,"score_spread":0.2510085315785343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}