{"id":"W2164252048","doi":"10.1210/jc.2003-030222","title":"A Pituitary-Derived MEG3 Isoform Functions as a Growth Suppressor in Tumor Cells","year":2003,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":448,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"U.S. Public Health Service; National Institutes of Health; Jarislowsky Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; Massachusetts General Hospital","keywords":"Pituitary tumors; Biology; Tumor suppressor gene; Corticotropic cell; Pituitary adenoma; Gene isoform; Cancer research; Ectopic expression; MEG3; Gene; Gene expression; Somatic cell; Pituitary gland; Adenoma; Molecular biology; Carcinogenesis; Genetics; Endocrinology; Downregulation and upregulation; Hormone","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008339529,0.0001888805,0.0001249111,0.0001661511,0.0001533846,0.0002217686,0.0001344437,0.0001508414,0.0007054335],"category_scores_gemma":[0.0001359184,0.00008515717,0.0001653487,0.0001225251,0.0002089425,0.0001210982,0.0001568359,0.0002878815,0.0003566137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002548909,"about_ca_system_score_gemma":0.0001855262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007412957,"about_ca_topic_score_gemma":0.0009977786,"domain_scores_codex":[0.9999529,0.000005943785,0.000003899873,0.000009806413,0.00001666899,0.00001072453],"domain_scores_gemma":[0.999916,0.00002390022,0.0000144317,0.00001391924,0.000009593814,0.00002227461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004623165,0.000002840387,0.0002711912,0.000005907726,0.000001001486,0.00006731247,0.000006405331,0.00001284171,0.9990925,0.00007598866,0.00001298146,0.0004049333],"study_design_scores_gemma":[0.00002169408,0.0001449433,0.01557158,0.000003079798,0.00001482823,0.001461199,0.00005442169,0.000655424,0.9772308,0.0002078856,0.004629745,0.000004389491],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957044,0.0008555186,0.001782044,0.0001043556,0.00002424435,0.000008382122,0.0003668716,0.00004864096,0.001105676],"genre_scores_gemma":[0.9961988,0.0003321093,0.00103887,0.00002787923,0.000009115197,0.000008299822,0.0008660044,0.00001505904,0.001503822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007412957,"threshold_uncertainty_score":0.002359867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02254738213074838,"score_gpt":0.3100039637456756,"score_spread":0.2874565816149273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}