{"id":"W2164272298","doi":"10.1212/wnl.0000000000000146","title":"Naive CD4 T-cell activation identifies MS patients having rapid transition to progressive MS","year":2014,"lang":"en","type":"article","venue":"Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"McGill University","keywords":"T-cell receptor; TLR2; Multiple sclerosis; Downregulation and upregulation; T cell; Flow cytometry; Biology; TLR4; Immunology; Gene; Microarray; Immune system; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001666466,0.000141444,0.0002531286,0.0001810878,0.0001377512,0.0000192545,0.00008942909,0.000100135,0.0001118486],"category_scores_gemma":[0.0006315341,0.0001240657,0.0000610468,0.0001541793,0.0001009235,0.0001016851,0.0000685383,0.000262245,0.00009926796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002665517,"about_ca_system_score_gemma":0.0000188856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007866754,"about_ca_topic_score_gemma":0.00001742741,"domain_scores_codex":[0.9985151,0.0002070375,0.0002120469,0.0003767788,0.0003431186,0.0003459457],"domain_scores_gemma":[0.9991126,0.0001986838,0.00007875852,0.0002169296,0.0002669737,0.0001260319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00624179,0.001516182,0.05886494,0.0004811128,0.0001602004,0.0000383547,0.007801939,0.0001538495,0.807003,0.00005325529,0.01535383,0.1023316],"study_design_scores_gemma":[0.002893252,0.005158782,0.9210436,0.00005581776,0.0000379678,0.000004597687,0.00003419666,0.0007314642,0.06549204,0.00004601483,0.004346733,0.0001555659],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919466,0.00002086013,0.0005296474,0.004815822,0.0002336153,0.0008402978,0.000005042524,0.00006937898,0.001538672],"genre_scores_gemma":[0.9965779,0.00002354336,0.0001181679,0.002785339,0.0002244898,0.0001428446,0.00004789014,0.00002301676,0.00005685613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8621786,"threshold_uncertainty_score":0.5059251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02391746793707293,"score_gpt":0.2912198181476536,"score_spread":0.2673023502105806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}