{"id":"W2164272298","doi":"10.1212/wnl.0000000000000146","title":"Naive CD4 T-cell activation identifies MS patients having rapid transition to progressive MS","year":2014,"lang":"en","type":"article","venue":"Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"McGill University","keywords":"T-cell receptor; TLR2; Multiple sclerosis; Downregulation and upregulation; T cell; Flow cytometry; Biology; TLR4; Immunology; Gene; Microarray; Immune system; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001465183,0.0003804711,0.0004723722,0.0007321499,0.0003648484,0.0004750184,0.0001761314,0.000578956,0.00222199],"category_scores_gemma":[0.0006327463,0.0001665522,0.0001956476,0.0004186478,0.0002555972,0.0003504206,0.000232597,0.0003142821,0.0003671563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001249459,"about_ca_system_score_gemma":0.000109504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004512352,"about_ca_topic_score_gemma":0.0004845982,"domain_scores_codex":[0.9998281,0.00002745405,0.00002406854,0.00006509505,0.00002488835,0.00003038927],"domain_scores_gemma":[0.9997115,0.00006041909,0.00009720353,0.00001961143,0.00004213365,0.00006909789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001378384,0.0001161623,0.9365997,0.00006835143,0.00006143295,0.001217538,0.0003041289,0.0001545259,0.05121583,0.00004470873,0.0001735016,0.008665719],"study_design_scores_gemma":[0.00003052611,0.0004669624,0.9913039,0.00001134486,0.00005185619,0.004808434,0.0003052467,0.0004619424,0.002149815,0.00008968332,0.0003121628,0.000008072191],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995514,0.0001258018,0.00007728412,0.00001257022,0.000002424111,0.000005273906,0.0000555357,0.000006873939,0.0001628477],"genre_scores_gemma":[0.9995019,0.0000479595,0.0001789002,0.0000162329,0.00001140644,0.000005843989,0.0001237433,0.000002356794,0.0001115587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00222199,"threshold_uncertainty_score":0.007433355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02391746793707293,"score_gpt":0.2912198181476536,"score_spread":0.2673023502105806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}