{"id":"W2164276007","doi":"10.1074/jbc.m110.123729","title":"The E3 Ubiquitin Ligase IDOL Induces the Degradation of the Low Density Lipoprotein Receptor Family Members VLDLR and ApoER2","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Herzfelder'sche Familienstiftung; Academy of Finland; Fondation pour la Recherche Médicale; Howard Hughes Medical Institute","keywords":"Liver X receptor; Ubiquitin ligase; Low-density lipoprotein receptor-related protein 8; Reelin; LDL receptor; Sterol regulatory element-binding protein; Cell biology; Receptor; Chemistry; Lipid metabolism; Signal transduction; Biology; Ubiquitin; Lipoprotein; Sterol; Biochemistry; Nuclear receptor; Cholesterol; Very low-density lipoprotein; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008880417,0.0001182016,0.0002539293,0.000008650184,0.0001488835,0.00002742697,0.0002516003,0.0001970609,0.00004475403],"category_scores_gemma":[0.001118631,0.00004173701,0.0001533593,0.00009112528,0.0004242436,0.00003619767,0.00008656129,0.0008895678,9.152809e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000124793,"about_ca_system_score_gemma":0.00007177489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001368182,"about_ca_topic_score_gemma":0.000004401159,"domain_scores_codex":[0.9990312,0.00006996685,0.0003929973,0.0001117283,0.0002506915,0.000143384],"domain_scores_gemma":[0.9987925,0.0002411506,0.0004473283,0.0002387211,0.0001740498,0.000106215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001981876,0.00005595173,0.001727771,0.00002388003,0.00002995094,0.000001989591,0.00005829568,1.910133e-7,0.9864069,0.00001719785,0.0004016075,0.01107807],"study_design_scores_gemma":[0.000553678,0.0000655157,0.08715647,0.00006943617,0.0000522496,0.0001528446,0.0004194252,0.000004038479,0.9029002,0.0001409359,0.008429717,0.00005551439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944829,0.0005324459,0.000003771089,0.004292026,0.0002905065,0.0001307793,0.000004915859,0.000005381984,0.0002572197],"genre_scores_gemma":[0.9979251,0.0003099017,0.0001131128,0.0004396281,0.0008959567,0.000002922529,0.000001811575,0.000004963755,0.0003066102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0854287,"threshold_uncertainty_score":0.3864779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01773139939845359,"score_gpt":0.2465383016832897,"score_spread":0.2288069022848362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}