{"id":"W2164276007","doi":"10.1074/jbc.m110.123729","title":"The E3 Ubiquitin Ligase IDOL Induces the Degradation of the Low Density Lipoprotein Receptor Family Members VLDLR and ApoER2","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Herzfelder'sche Familienstiftung; Academy of Finland; Fondation pour la Recherche Médicale; Howard Hughes Medical Institute","keywords":"Liver X receptor; Ubiquitin ligase; Low-density lipoprotein receptor-related protein 8; Reelin; LDL receptor; Sterol regulatory element-binding protein; Cell biology; Receptor; Chemistry; Lipid metabolism; Signal transduction; Biology; Ubiquitin; Lipoprotein; Sterol; Biochemistry; Nuclear receptor; Cholesterol; Very low-density lipoprotein; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001815276,0.0003542509,0.0002811814,0.0003248202,0.0001224726,0.0003657042,0.0001313716,0.0001648919,0.001276758],"category_scores_gemma":[0.0001444771,0.0001696628,0.0002699981,0.0001520959,0.0002308971,0.0001193682,0.0002867182,0.0003309579,0.0004528718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003414104,"about_ca_system_score_gemma":0.0001886407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003928634,"about_ca_topic_score_gemma":0.0008241326,"domain_scores_codex":[0.9998202,0.00003906072,0.00001472758,0.00002866683,0.00004340811,0.00005396634],"domain_scores_gemma":[0.9999024,0.00001249653,0.00002677851,0.00001819256,0.00001332063,0.00002677279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001894757,0.00002112946,0.0002411249,0.00002783615,0.000008571657,0.00007706948,0.000007027043,0.00002524637,0.9977471,0.00009255995,0.00006022491,0.001502617],"study_design_scores_gemma":[0.00002373765,0.0001644663,0.003286308,0.000003186347,0.00001406067,0.0003210331,0.00001647035,0.0003327742,0.9937236,0.00005340666,0.002058252,0.00000263726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909036,0.002928888,0.003471864,0.0001924903,0.00003829151,0.0000188714,0.0002438944,0.0001707575,0.002031351],"genre_scores_gemma":[0.9908275,0.00139228,0.002150933,0.00009531847,0.00001395312,0.00001887636,0.0004273744,0.00002961286,0.00504416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001276758,"threshold_uncertainty_score":0.004271209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01773139939845359,"score_gpt":0.2465383016832897,"score_spread":0.2288069022848362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}