{"id":"W2164303345","doi":"10.1074/jbc.m112331200","title":"The Hexosamine Pathway Regulates the Plasminogen Activator Inhibitor-1 Gene Promoter and Sp1 Transcriptional Activation through Protein Kinase C-βI and -δ","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Mount Sinai Hospital; University of Toronto","funders":"Juvenile Diabetes Research Foundation International","keywords":"Protein kinase C; Sp1 transcription factor; Activator (genetics); Molecular biology; Promoter; Signal transduction; Reporter gene; Biology; Luciferase; Transcription factor; Transcriptional regulation; Chemistry; Gene expression; Biochemistry; Gene; Transfection","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002174224,0.0001220302,0.0001964782,0.000008732374,0.0001523416,0.00003343975,0.00005678193,0.0001313781,0.0001629241],"category_scores_gemma":[0.0003786705,0.00005197026,0.00006965538,0.00006025488,0.0002438926,0.00007819995,0.000018781,0.0002654572,0.000001067641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002945179,"about_ca_system_score_gemma":0.00002064094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.902481e-7,"about_ca_topic_score_gemma":3.027569e-8,"domain_scores_codex":[0.9992404,0.00003858942,0.0002780252,0.0001258632,0.0001790575,0.0001380389],"domain_scores_gemma":[0.9993697,0.0001810025,0.0001735572,0.00009793187,0.00008575148,0.00009203892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000263381,0.00009364738,0.0008969842,0.00003098111,0.00005461421,0.00001051975,0.00007618398,2.120466e-7,0.996004,0.00002179231,0.000315332,0.002232286],"study_design_scores_gemma":[0.001041742,0.0003133689,0.008796699,0.00009102454,0.00002673497,0.0003589398,0.0001382133,0.00004662826,0.9806554,0.0004147402,0.008045986,0.00007057237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928918,0.001666688,0.00001758394,0.004801541,0.00003232096,0.0001591659,0.000005205643,0.000009530594,0.0004161019],"genre_scores_gemma":[0.9981385,0.000216281,0.0003379089,0.000215274,0.0004400294,0.000009921413,0.000004443805,0.000005555296,0.0006321174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01534872,"threshold_uncertainty_score":0.2119286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03237920261563353,"score_gpt":0.226771824494753,"score_spread":0.1943926218791194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}