{"id":"W2164327707","doi":"10.1096/fj.04-3437fje","title":"Dopamine promotes α‐synuclein aggregation into SDS‐resistant soluble oligomers via a distinct folding pathway","year":2005,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":257,"is_retracted":false,"has_abstract":true,"ca_institutions":"Victoria Park","funders":"National Health and Medical Research Council","keywords":"Alpha-synuclein; Fibril; Circular dichroism; Thioflavin; Oligomer; Chemistry; Biophysics; Protein aggregation; Amyloid (mycology); Protein folding; Folding (DSP implementation); Dopamine; Neurodegeneration; Biochemistry; Crystallography; Parkinson's disease; Alzheimer's disease; Biology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001121588,0.0002167655,0.0001556614,0.0001225573,0.0001083127,0.0002603721,0.00006780872,0.0001611297,0.0004701566],"category_scores_gemma":[0.00007427939,0.0001305371,0.0002267978,0.00004996529,0.0001324675,0.0001510836,0.000106152,0.0002719321,0.0002460486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000200821,"about_ca_system_score_gemma":0.0001008399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001984871,"about_ca_topic_score_gemma":0.0003753339,"domain_scores_codex":[0.9999363,0.00001659202,0.000006454887,0.00001123109,0.00001554475,0.00001394632],"domain_scores_gemma":[0.9999312,0.00001128375,0.00001764724,0.000006895682,0.00001385323,0.00001916701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001038359,0.0000418448,0.0001445629,0.00003202822,0.000005592075,0.00007233933,0.00001552979,0.00001651704,0.998723,0.00009427228,0.00002946672,0.0007210134],"study_design_scores_gemma":[0.00003843601,0.0005053391,0.01209612,0.00001271438,0.00001679536,0.000497032,0.00003587338,0.0008446033,0.983993,0.0001423924,0.001811824,0.000005894668],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953333,0.002284537,0.0009122107,0.0000790253,0.00001877393,0.00002064488,0.00007130481,0.00002476144,0.001255469],"genre_scores_gemma":[0.9961995,0.001248607,0.0008778878,0.00003891174,0.000009752103,0.00001556127,0.0001315643,0.000006201511,0.001471997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004701566,"threshold_uncertainty_score":0.001572847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0150621685132416,"score_gpt":0.2496574948006818,"score_spread":0.2345953262874401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}