{"id":"W2164358303","doi":"10.2337/db15-0518","title":"Comment on Rickels et al. Loss-of-Function Mutations in <i>ABCA1</i> and Enhanced β-Cell Secretory Capacity in Young Adults. Diabetes 2015;64:193–199","year":2015,"lang":"en","type":"letter","venue":"Diabetes","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"","keywords":"ABCA1; Type 2 diabetes; Endocrinology; Internal medicine; Diabetes mellitus; Insulin; Cholesterol; Tangier disease; Disease; Intracellular; Biology; Medicine; Cell biology; Gene; Genetics; Transporter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001953832,0.001432575,0.001911152,0.0009138332,0.001678287,0.002287354,0.002823067,0.02702347,0.004552184],"category_scores_gemma":[0.01382841,0.000803154,0.001523644,0.0007360223,0.002006402,0.003412833,0.001009363,0.02576647,0.00600653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002998489,"about_ca_system_score_gemma":0.00134097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002291977,"about_ca_topic_score_gemma":0.003090316,"domain_scores_codex":[0.9982051,0.0004116792,0.0002747597,0.000362529,0.0005105715,0.000235289],"domain_scores_gemma":[0.9970701,0.001341931,0.0002907172,0.0001174446,0.0006734456,0.0005063476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001248836,0.00007557796,0.0008903431,0.0001216468,0.00003930967,0.006826129,0.00009667491,0.00007571524,0.00030274,0.000848738,0.9840095,0.006588746],"study_design_scores_gemma":[0.0003317373,0.0003934186,0.005519456,0.0007255261,0.0001811093,0.02615259,0.0005428076,0.001468131,0.001198991,0.00711859,0.9561427,0.0002250273],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001474471,0.003679955,0.000257467,0.8968226,0.09515572,0.00003490963,0.0001747105,0.0001557953,0.002244414],"genre_scores_gemma":[0.008954899,0.0023734,0.0002965069,0.8247595,0.1574227,0.00005466768,0.00009729075,0.00005807502,0.005982833],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02702347,"threshold_uncertainty_score":0.02175564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01887368059582339,"score_gpt":0.2474831754522475,"score_spread":0.2286094948564241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}