{"id":"W2164377036","doi":"10.1161/01.res.0000223321.34482.8c","title":"Insulin-Like Growth Factor-1 and PTEN Deletion Enhance Cardiac L-Type Ca <sup>2+</sup> Currents via Increased PI3Kα/PKB Signaling","year":2006,"lang":"en","type":"article","venue":"Circulation Research","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"PTEN; Internal medicine; Endocrinology; Phosphoinositide 3-kinase; Protein kinase B; Phosphatase; Myocyte; Biology; Contractility; PI3K/AKT/mTOR pathway; Chemistry; Signal transduction; Cell biology; Phosphorylation; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001648837,0.0004532732,0.0002828834,0.0003491948,0.0001294416,0.0004161221,0.0003651614,0.0003590338,0.001770702],"category_scores_gemma":[0.00015088,0.0002769711,0.0003775189,0.0002239376,0.0004160786,0.0003862462,0.0003070851,0.0009657039,0.0004968721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000285433,"about_ca_system_score_gemma":0.0002540716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005905274,"about_ca_topic_score_gemma":0.0008178705,"domain_scores_codex":[0.9997975,0.00001835757,0.00003247582,0.00003826324,0.00005576913,0.00005772587],"domain_scores_gemma":[0.999749,0.00002152326,0.00006703897,0.0000195206,0.00001185696,0.0001310008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003685336,0.00007357258,0.0001561809,0.000021531,0.000005683136,0.00006778572,0.00001099397,0.00004290705,0.9985206,0.0000804809,0.00004438968,0.0006074605],"study_design_scores_gemma":[0.0001535426,0.001062118,0.01179655,0.00001076173,0.00003839917,0.0004411289,0.00007800919,0.001450105,0.9821952,0.0001093993,0.002652365,0.00001248021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964293,0.000435508,0.0009711165,0.0001324296,0.00005042852,0.00002521076,0.0003527453,0.0001226811,0.001480684],"genre_scores_gemma":[0.9937834,0.0004949308,0.00134105,0.0001031034,0.00002339079,0.00006442442,0.000541629,0.00004061756,0.003607473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001770702,"threshold_uncertainty_score":0.005923569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02767299068232306,"score_gpt":0.3055778889435961,"score_spread":0.2779048982612731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}