{"id":"W2164382188","doi":"","title":"Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms.","year":2002,"lang":"en","type":"article","venue":"PubMed","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":510,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Medicine; Pharmacokinetics; Depsipeptide; Nausea; Refractory (planetary science); Vomiting; Toxicity; Maximum tolerated dose; Internal medicine; Pharmacology; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004993608,0.001315273,0.001554958,0.0003171204,0.0002878499,0.0004628232,0.0006174913,0.0007438496,0.00246609],"category_scores_gemma":[0.0003541548,0.0002596051,0.0004899694,0.0003308882,0.0004288046,0.0003856281,0.0002613796,0.001665299,0.0006814298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007030637,"about_ca_system_score_gemma":0.001074363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009260927,"about_ca_topic_score_gemma":0.003110702,"domain_scores_codex":[0.9998648,0.00004563155,0.00001080435,0.00002431243,0.00001904571,0.00003531383],"domain_scores_gemma":[0.9997119,0.00004557196,0.00006742554,0.00001583114,0.00001667846,0.0001424979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4486631,0.0400783,0.01232567,0.002168259,0.001411828,0.001645537,0.0004955551,0.005598045,0.1733724,0.0006090495,0.01283438,0.3007978],"study_design_scores_gemma":[0.3956994,0.5538434,0.01734948,0.0001058462,0.0007347777,0.001967252,0.0001140255,0.002961876,0.01762332,0.0003197725,0.009247132,0.0000337848],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919218,0.003091044,0.0003936366,0.0003123032,0.00007449753,0.001293197,0.0005568021,0.00009677598,0.002259915],"genre_scores_gemma":[0.9867154,0.002846527,0.001633887,0.0007555973,0.0001828725,0.001834217,0.002706787,0.00002536657,0.003299442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00246609,"threshold_uncertainty_score":0.008249879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01404261064377119,"score_gpt":0.242349608075614,"score_spread":0.2283069974318428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}