{"id":"W2164382188","doi":"","title":"Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms.","year":2002,"lang":"en","type":"article","venue":"PubMed","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":510,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Medicine; Pharmacokinetics; Depsipeptide; Nausea; Refractory (planetary science); Vomiting; Toxicity; Maximum tolerated dose; Internal medicine; Pharmacology; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003668334,0.0002407256,0.000279671,0.0001328466,0.00009017521,0.0000168579,0.0003847759,0.0002106257,0.00002880037],"category_scores_gemma":[0.000471928,0.0001816225,0.0001381421,0.0003400384,0.0002942858,0.00001423954,0.0001650524,0.0003144429,0.00001206959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001681704,"about_ca_system_score_gemma":0.0000735592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007203229,"about_ca_topic_score_gemma":0.0002183826,"domain_scores_codex":[0.9976815,0.0002212996,0.0004631532,0.0004740309,0.0005834,0.0005766315],"domain_scores_gemma":[0.9986511,0.00003538551,0.0002170185,0.0007857936,0.0001279908,0.0001826591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1839449,0.05562228,0.04547465,0.0004257842,0.0007189882,0.0001088676,0.001341789,0.0002390805,0.1773075,0.00006892605,0.1727968,0.3619505],"study_design_scores_gemma":[0.2435105,0.00351893,0.04077141,0.00006581207,0.00006556098,0.000008613166,0.00004347009,0.00003493373,0.6226063,0.000007003964,0.08852328,0.0008442612],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958363,0.0002760237,0.000006806886,0.0001236584,0.0003526642,0.001721359,0.00004520988,0.00001300699,0.001625038],"genre_scores_gemma":[0.9970073,0.00003038759,0.00005226751,0.00008390261,0.0002256873,0.0007012297,0.00004715602,0.00004747139,0.00180467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4452988,"threshold_uncertainty_score":0.7406351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01404261064377119,"score_gpt":0.242349608075614,"score_spread":0.2283069974318428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}