{"id":"W2164419903","doi":"10.1093/nar/gkh265","title":"Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21","year":2004,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; Tel Aviv University; Natural Sciences and Engineering Research Council of Canada; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Alberta Cancer Foundation; University of Dundee; University of Oklahoma","keywords":"Biology; Replication protein A; Phosphorylation; Protein phosphorylation; DNA-PKcs; Origin recognition complex; DNA damage; Autophagy-related protein 13; Eukaryotic DNA replication; DNA replication; Phosphorylation cascade; DNA repair; Replication factor C; Cell biology; Biochemistry; Molecular biology; Protein kinase A; DNA; DNA-binding protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007978218,0.0004318253,0.0002214261,0.000166259,0.000185754,0.0002928092,0.0001854826,0.0002667438,0.001472175],"category_scores_gemma":[0.0001485463,0.0002162661,0.0002891923,0.0001302378,0.0001797734,0.0002159719,0.0002976933,0.0005314421,0.0009226235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003133391,"about_ca_system_score_gemma":0.0002192486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004992678,"about_ca_topic_score_gemma":0.0006572445,"domain_scores_codex":[0.9998909,0.00001233652,0.00001422505,0.00002009888,0.00002943559,0.0000329895],"domain_scores_gemma":[0.9998752,0.00001482133,0.00004863201,0.00001024085,0.000008761641,0.00004228637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001170671,0.00001495658,0.0001603269,0.00003295003,0.000003409863,0.0001124962,0.000006025292,0.00003956523,0.9986411,0.00006663354,0.0000459926,0.000759446],"study_design_scores_gemma":[0.00004477438,0.0001783891,0.01415684,0.000008775227,0.0000242909,0.0008873325,0.00003196751,0.001309705,0.9775971,0.0001121937,0.005639941,0.000008814623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989327,0.003089545,0.003395126,0.0002430757,0.00007686947,0.00005549175,0.0009075777,0.0003078772,0.002597421],"genre_scores_gemma":[0.9916972,0.001410731,0.002117794,0.00008796168,0.00001451057,0.00004860889,0.001240559,0.00002815865,0.003354407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001472175,"threshold_uncertainty_score":0.004924893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03837115255004962,"score_gpt":0.3129064609294454,"score_spread":0.2745353083793957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}