{"id":"W2164438960","doi":"10.1002/pro.2617","title":"Combinatorial active‐site variants confer sustained clavulanate resistance in <scp>B</scp>laC β‐lactamase from <scp><i>M</i></scp><i>ycobacterium tuberculosis</i>","year":2014,"lang":"en","type":"article","venue":"Protein Science","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université Laval; PROTEO; Institut National de la Recherche Scientifique","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Fonds de Recherche du Québec - Santé; Universitaire Stichting","keywords":"Microbiology; Mycobacterium tuberculosis; Chemistry; Tuberculosis; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001648036,0.0003839438,0.0002974113,0.0001921815,0.0001277831,0.000430756,0.0003658527,0.0002865138,0.0008853919],"category_scores_gemma":[0.0001832027,0.0001581799,0.0002778179,0.0002214787,0.000222,0.0001242256,0.0002550368,0.0005400618,0.0003724148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003323868,"about_ca_system_score_gemma":0.0002571437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009916967,"about_ca_topic_score_gemma":0.001434889,"domain_scores_codex":[0.9997222,0.0000412409,0.00004019123,0.00004472637,0.00009441702,0.00005731511],"domain_scores_gemma":[0.9998491,0.00002339021,0.00004968997,0.00002469278,0.0000133481,0.0000397513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001230833,0.0000913188,0.0001607711,0.00001797099,0.00001143234,0.00006727104,0.00001391975,0.0001668977,0.9981776,0.00007772872,0.00003309494,0.00105891],"study_design_scores_gemma":[0.0000211902,0.0006429523,0.001461462,0.000003796585,0.00002270105,0.0003124768,0.00002465257,0.001322847,0.9946725,0.00001546634,0.001491079,0.000009011444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978806,0.0002156084,0.001004502,0.00002796716,0.00001787994,0.00002495695,0.0001451323,0.00004815495,0.000635296],"genre_scores_gemma":[0.9963882,0.0001457512,0.001843666,0.0000259933,0.000006406828,0.00002362547,0.0003741649,0.0000425763,0.001149622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009916967,"threshold_uncertainty_score":0.002961934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005580894017759944,"score_gpt":0.2286310544165405,"score_spread":0.2230501603987806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}