{"id":"W2164438960","doi":"10.1002/pro.2617","title":"Combinatorial active‐site variants confer sustained clavulanate resistance in <scp>B</scp>laC β‐lactamase from <scp><i>M</i></scp><i>ycobacterium tuberculosis</i>","year":2014,"lang":"en","type":"article","venue":"Protein Science","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université Laval; PROTEO; Institut National de la Recherche Scientifique","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Fonds de Recherche du Québec - Santé; Universitaire Stichting","keywords":"Microbiology; Mycobacterium tuberculosis; Chemistry; Tuberculosis; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001521684,0.0005446982,0.0005486296,0.0002061176,0.0003581735,0.0003737329,0.001353856,0.0004065938,0.00001309603],"category_scores_gemma":[0.005769846,0.0005401957,0.0001362552,0.0008560507,0.001085732,0.0001146191,0.000562232,0.0004241818,0.00007703561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001676314,"about_ca_system_score_gemma":0.0005336187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001786387,"about_ca_topic_score_gemma":0.0002775149,"domain_scores_codex":[0.9951459,0.0003780167,0.0006776492,0.001664185,0.0008219956,0.001312311],"domain_scores_gemma":[0.9970421,0.0002937481,0.0004253521,0.001348639,0.0004952687,0.0003949089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001116245,0.0001637708,0.006166233,0.00005787587,0.00002935699,0.00002563624,0.0004700444,0.000004464902,0.9894231,0.002134515,0.001302243,0.000111141],"study_design_scores_gemma":[0.002736564,0.0002739648,0.08052491,0.0002105193,0.00003376589,0.000005901725,0.0005114325,0.0001944191,0.8231883,0.005115944,0.08689979,0.0003044993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869503,0.0002161881,0.0009595492,0.0001927813,0.0009583075,0.0009961639,0.0001288112,0.00006056026,0.009537378],"genre_scores_gemma":[0.9952404,0.00005959412,0.00178506,0.0003317925,0.000542708,0.00007592489,0.0001205923,0.00006449629,0.00177939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1662348,"threshold_uncertainty_score":0.999705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005580894017759944,"score_gpt":0.2286310544165405,"score_spread":0.2230501603987806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}