{"id":"W2164489422","doi":"10.1071/ch03105","title":"Novel Disulfides with Antitumour Efficacy and Specificity","year":2005,"lang":"en","type":"article","venue":"Australian Journal of Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Allison University; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Organosulfur compounds; Cytotoxicity; Biocatalysis; Apoptosis; Mechanism of action; Biochemistry; Macromolecule; Combinatorial chemistry; Programmed cell death; Stereochemistry; In vitro; Reaction mechanism; Sulfur; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001449735,0.0001705203,0.0002882153,0.00001150283,0.00005345948,0.00005537895,0.0002006162,0.0001210265,0.001294468],"category_scores_gemma":[0.0000924098,0.0001091545,0.00007993807,0.00005214482,0.0001639088,0.0001393396,0.00002752605,0.0003424809,0.000003684837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003540624,"about_ca_system_score_gemma":0.00003046896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003184598,"about_ca_topic_score_gemma":9.264076e-7,"domain_scores_codex":[0.9990987,0.000005656895,0.0003091941,0.0001699929,0.0002031074,0.0002133997],"domain_scores_gemma":[0.9991804,0.0001030093,0.0003072522,0.0001402294,0.00007485065,0.0001942718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000157048,0.0002793827,0.007936521,0.00005026509,0.00005445617,0.00003256771,0.0000171895,0.000009856586,0.983067,0.000003067244,0.0002714008,0.008121251],"study_design_scores_gemma":[0.0008048054,0.00003680461,0.01352529,0.0001401368,0.00004145848,0.0009119377,0.00009921788,0.000001470308,0.9764285,0.00001485,0.007826279,0.0001692277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950655,0.00009699995,0.00003523592,0.000963361,0.00001266749,0.00001309842,0.00001293619,0.00001329239,0.003786973],"genre_scores_gemma":[0.9960284,0.00005058136,0.001922827,0.00002029415,0.000655732,4.229581e-7,0.000001547272,0.000009794059,0.001310405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007952024,"threshold_uncertainty_score":0.9996185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02847417574421015,"score_gpt":0.2467859367987449,"score_spread":0.2183117610545347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}