{"id":"W2164489422","doi":"10.1071/ch03105","title":"Novel Disulfides with Antitumour Efficacy and Specificity","year":2005,"lang":"en","type":"article","venue":"Australian Journal of Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Allison University; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Organosulfur compounds; Cytotoxicity; Biocatalysis; Apoptosis; Mechanism of action; Biochemistry; Macromolecule; Combinatorial chemistry; Programmed cell death; Stereochemistry; In vitro; Reaction mechanism; Sulfur; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001827799,0.0003245315,0.0001886332,0.0001984101,0.000100434,0.0001919881,0.0002403888,0.0002637212,0.001143238],"category_scores_gemma":[0.0001182555,0.00009289756,0.0002193879,0.000159343,0.0001693442,0.0001990202,0.0001463493,0.0002987201,0.0002430963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001530681,"about_ca_system_score_gemma":0.0001435993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001460642,"about_ca_topic_score_gemma":0.0003313993,"domain_scores_codex":[0.9999208,0.00001852199,0.000009027411,0.00001394911,0.0000222593,0.00001535929],"domain_scores_gemma":[0.9999088,0.00001360374,0.00002524698,0.000008421628,0.00002253014,0.00002130838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001816703,0.00003531122,0.0001379345,0.00009072784,0.000007714316,0.00008269031,0.00001702851,0.00019615,0.9930734,0.0002800038,0.00007065312,0.005826741],"study_design_scores_gemma":[0.00003285176,0.001468587,0.0007445887,0.000005969043,0.00001982228,0.0004306789,0.00001161717,0.0002605504,0.991694,0.0000565125,0.005269851,0.000004868563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867901,0.003843562,0.004493957,0.0001251134,0.00004610186,0.000102856,0.0002613343,0.00009761626,0.004239355],"genre_scores_gemma":[0.9878091,0.002495851,0.005475824,0.0001163473,0.0000327157,0.00004086854,0.0004922281,0.00001421419,0.003522786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001143238,"threshold_uncertainty_score":0.003824532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02847417574421015,"score_gpt":0.2467859367987449,"score_spread":0.2183117610545347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}