{"id":"W2164529810","doi":"10.1093/cvr/cvt011","title":"FGF-2 protects cardiomyocytes from doxorubicin damage via protein kinase C-dependent effects on efflux transporters","year":2013,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital; University of Manitoba","funders":"National Institutes of Health","keywords":"Efflux; Pharmacology; Calcein; Lactate dehydrogenase; Tyrosine-kinase inhibitor; Protein kinase C; Biology; Chemistry; Biochemistry; Kinase; Internal medicine; Medicine; Cancer; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0024161,0.0004466716,0.001113654,0.0004847768,0.0003139735,0.0001439436,0.0003476212,0.0004252621,0.0001826412],"category_scores_gemma":[0.0003548494,0.0003955835,0.001551059,0.000719559,0.0002465883,0.0002335397,0.0000775832,0.001497944,0.0007866695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005687464,"about_ca_system_score_gemma":0.000229272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002217162,"about_ca_topic_score_gemma":0.00001098558,"domain_scores_codex":[0.9933919,0.001117603,0.0003960468,0.001112137,0.002972441,0.001009927],"domain_scores_gemma":[0.9965374,0.0002595427,0.00005200821,0.002010918,0.0005591274,0.0005810204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002246694,0.0001446868,0.0002366687,0.0005268622,0.002428781,0.0006359139,0.000388256,0.00006415691,0.9013031,0.0000213565,0.0003570215,0.09366854],"study_design_scores_gemma":[0.004754241,0.0006558763,0.01596432,0.0007299921,0.0002334931,0.00004298981,0.0001723769,0.00009555131,0.9727055,0.0003746488,0.003888328,0.0003826753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827728,0.001814434,0.001744158,0.0006372748,0.0001619034,0.009539306,0.00001554874,0.0002156496,0.003098933],"genre_scores_gemma":[0.9950111,0.00009490224,0.0003650209,0.0002166563,0.001034217,0.00241551,0.0001208331,0.0001318313,0.0006099307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09328587,"threshold_uncertainty_score":0.9999914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03085362239575024,"score_gpt":0.2885407175242677,"score_spread":0.2576870951285175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}