{"id":"W2164542791","doi":"10.1093/genetics/154.3.1291","title":"Mutation Frequency and Specificity With Age in Liver, Bladder and Brain of lacI Transgenic Mice","year":2000,"lang":"en","type":"article","venue":"Genetics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"","keywords":"Biology; Mutation; Mutation frequency; Lac repressor; Mutant; Somatic cell; Genetics; DNA; DNA damage; Mutagenesis; Genetically modified mouse; DNA repair; Molecular biology; Gene; Transgene; Plasmid; lac operon","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002554939,0.0003250922,0.0003060668,0.002099786,0.0001411605,0.0002964697,0.0001994222,0.0003151117,0.001038967],"category_scores_gemma":[0.0004433444,0.0002671469,0.0002115142,0.0003944476,0.0002540125,0.0002480775,0.0001776623,0.0004490027,0.0002963064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001768837,"about_ca_system_score_gemma":0.0001004052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000620871,"about_ca_topic_score_gemma":0.0008605603,"domain_scores_codex":[0.9997733,0.00002366761,0.00002565877,0.00009161651,0.00004854717,0.00003730396],"domain_scores_gemma":[0.9990835,0.000135456,0.0003967465,0.00006670643,0.0001122803,0.0002052521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001518786,0.00001170278,0.002247293,0.0000137379,0.000006473156,0.00004614799,0.00003008571,0.00002620264,0.9962825,0.00002322751,0.00001194826,0.001148745],"study_design_scores_gemma":[0.00001684326,0.0009270136,0.1706486,0.00001379164,0.00007838498,0.001841834,0.00007868764,0.0007476712,0.8245193,0.000136566,0.0009631945,0.00002826123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955521,0.0007653243,0.00227587,0.00002566566,0.000006335591,0.00001229059,0.0005981908,0.0001310253,0.0006332109],"genre_scores_gemma":[0.9902262,0.001205229,0.003220925,0.00003958527,0.0000107094,0.00005423446,0.001324731,0.0001026398,0.003815765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002099786,"threshold_uncertainty_score":0.003475726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007299574370335546,"score_gpt":0.210035902938347,"score_spread":0.2027363285680115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}