{"id":"W2164550834","doi":"10.1002/emmm.201200229","title":"Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53","year":2012,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa; University of Calgary","funders":"National Cancer Institute; Leukemia and Lymphoma Society of Canada; Canadian Institutes of Health Research; Alberta Cancer Foundation; Leukemia and Lymphoma Society; AstraZeneca; Alberta Innovates; University of Calgary; Cancer Research Institute","keywords":"Olaparib; Poly ADP ribose polymerase; DNA damage; Cancer research; Mantle cell lymphoma; PARP inhibitor; DNA repair; Biology; Cytotoxicity; Chemistry; Molecular biology; Cell biology; Polymerase; DNA; Lymphoma; Immunology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004449222,0.0001680391,0.0004180926,0.0003404382,0.00002469029,0.000002837503,0.00004385656,0.0001022722,0.0001454079],"category_scores_gemma":[0.0001280534,0.0001591076,0.00003993271,0.0004232095,0.0001791892,0.0001130839,0.00003410654,0.0001495217,0.000006502712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001737994,"about_ca_system_score_gemma":0.0000638356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000168275,"about_ca_topic_score_gemma":0.00002496129,"domain_scores_codex":[0.9985445,0.00009286247,0.0004862948,0.0002330494,0.0003217358,0.0003216275],"domain_scores_gemma":[0.9992816,0.00006703189,0.0001426287,0.0003008918,0.00004777447,0.0001601132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001306249,0.0003727433,0.006337738,0.0001887795,0.00001440579,0.00008895835,0.002257047,0.00002801868,0.9894654,0.0003314124,0.00006805733,0.0007167733],"study_design_scores_gemma":[0.009595869,0.0002324138,0.1207456,0.0009381661,0.00003931801,0.00005377754,0.0004632357,0.0001379068,0.8670208,0.0005223547,0.0001042784,0.0001462514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877362,0.002530755,0.003103488,0.0009224152,0.0001041241,0.0004550285,0.000005082775,0.00002557715,0.005117362],"genre_scores_gemma":[0.9979276,0.0002101718,0.0007607647,0.0007943423,0.0001252957,0.00006585137,0.00003446831,0.00002818053,0.00005333617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1224446,"threshold_uncertainty_score":0.6488221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01431239084984722,"score_gpt":0.2863096454055635,"score_spread":0.2719972545557163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}