{"id":"W2164550834","doi":"10.1002/emmm.201200229","title":"Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53","year":2012,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa; University of Calgary","funders":"National Cancer Institute; Leukemia and Lymphoma Society of Canada; Canadian Institutes of Health Research; Alberta Cancer Foundation; Leukemia and Lymphoma Society; AstraZeneca; Alberta Innovates; University of Calgary; Cancer Research Institute","keywords":"Olaparib; Poly ADP ribose polymerase; DNA damage; Cancer research; Mantle cell lymphoma; PARP inhibitor; DNA repair; Biology; Cytotoxicity; Chemistry; Molecular biology; Cell biology; Polymerase; DNA; Lymphoma; Immunology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001354225,0.0002572867,0.0003676211,0.0003290146,0.000129319,0.0003729728,0.000243059,0.0002491612,0.001200529],"category_scores_gemma":[0.0001537169,0.0001061432,0.0001790742,0.0002410859,0.0001430566,0.0002119436,0.0001691701,0.0005109999,0.0002694946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001891414,"about_ca_system_score_gemma":0.0001390712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003425272,"about_ca_topic_score_gemma":0.0005709316,"domain_scores_codex":[0.9998822,0.00003705959,0.00001142283,0.00001506708,0.00002842519,0.00002587694],"domain_scores_gemma":[0.9999151,0.00002877369,0.00001401847,0.00001427947,0.00000943252,0.00001832123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006923331,0.0001667063,0.0003830403,0.00004604698,0.00001513717,0.0001071729,0.00001797632,0.0003825474,0.9912866,0.000110382,0.0001170199,0.006675021],"study_design_scores_gemma":[0.0001211838,0.002787262,0.003893946,0.000005140432,0.0000305537,0.0005888417,0.00001522743,0.001475278,0.9894531,0.00004993616,0.001573598,0.000006046901],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951811,0.002289092,0.0009251701,0.00007263672,0.0000239797,0.00001645015,0.0001466257,0.00006634869,0.001278664],"genre_scores_gemma":[0.9979961,0.0006360847,0.000482366,0.00002170484,0.00000858467,0.00001184317,0.0002090943,0.000006532535,0.0006278633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001200529,"threshold_uncertainty_score":0.004016161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01431239084984722,"score_gpt":0.2863096454055635,"score_spread":0.2719972545557163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}