{"id":"W2164558617","doi":"10.2353/ajpath.2009.080660","title":"Development of a Rab9 Transgenic Mouse and Its Ability to Increase the Lifespan of a Murine Model of Niemann-Pick Type C Disease","year":2008,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; Fondation pour la Recherche Médicale; Natural Sciences and Engineering Research Council of Canada; National Niemann-Pick Disease Foundation; Alberta Heritage Foundation for Medical Research; Ara Parseghian Medical Research Foundation","keywords":"Transgene; Genetically modified mouse; Biology; In vivo; Gene knockin; Niemann–Pick disease; Rab; Wild type; Cell biology; Molecular biology; GTPase; Mutant; Endocrinology; Cholesterol; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005239511,0.0001111734,0.0006010502,0.0001847637,0.00003591562,8.970748e-7,0.0001841564,0.00002800407,0.00002351001],"category_scores_gemma":[0.0006825274,0.00007493143,0.0001026511,0.0003244655,0.000552414,0.00003511451,0.00006749028,0.0001886667,0.000001145319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003870568,"about_ca_system_score_gemma":0.0007758667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004161281,"about_ca_topic_score_gemma":0.00001146385,"domain_scores_codex":[0.9984743,0.0001899711,0.0006406706,0.000139597,0.0003657805,0.0001896994],"domain_scores_gemma":[0.9984521,0.0001051107,0.0003709264,0.0002323582,0.0005356882,0.0003037645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01676813,0.002444412,0.1116144,0.0006480646,0.0003462639,0.000613623,0.02635064,0.001190819,0.8235914,0.00007752276,0.0001375125,0.01621723],"study_design_scores_gemma":[0.01065847,0.01401579,0.877707,0.0003859416,0.0007122468,0.002361821,0.005678697,0.002585829,0.08476382,0.0002611621,0.0002979132,0.0005713115],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980794,0.0003961925,0.0005312107,0.0006921986,0.00001219205,0.0002423185,0.00001384159,0.000002859893,0.00002978808],"genre_scores_gemma":[0.9946874,0.0002041573,0.004887828,0.000132644,0.00001543367,0.00000452001,0.000001308091,0.00001272677,0.00005401935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7660927,"threshold_uncertainty_score":0.3055615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03899790878574015,"score_gpt":0.3107919561118662,"score_spread":0.2717940473261261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}