{"id":"W2164558617","doi":"10.2353/ajpath.2009.080660","title":"Development of a Rab9 Transgenic Mouse and Its Ability to Increase the Lifespan of a Murine Model of Niemann-Pick Type C Disease","year":2008,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; Fondation pour la Recherche Médicale; Natural Sciences and Engineering Research Council of Canada; National Niemann-Pick Disease Foundation; Alberta Heritage Foundation for Medical Research; Ara Parseghian Medical Research Foundation","keywords":"Transgene; Genetically modified mouse; Biology; In vivo; Gene knockin; Niemann–Pick disease; Rab; Wild type; Cell biology; Molecular biology; GTPase; Mutant; Endocrinology; Cholesterol; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007119923,0.0008829041,0.0004111923,0.001589695,0.0005764073,0.000487475,0.0007898212,0.001355202,0.003344935],"category_scores_gemma":[0.0004916909,0.0005310985,0.0006670351,0.0002785882,0.0006534178,0.0006900646,0.0003947647,0.001973598,0.001146162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005859771,"about_ca_system_score_gemma":0.0005069113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009588109,"about_ca_topic_score_gemma":0.001280538,"domain_scores_codex":[0.9996245,0.00006054061,0.00007354,0.00008887316,0.00008483118,0.00006775933],"domain_scores_gemma":[0.9991096,0.0001499568,0.0002158929,0.0001097227,0.0001114294,0.0003032956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002439021,0.0001071145,0.0001002901,0.00003574066,0.00001074016,0.0001553998,0.00002659523,0.000117037,0.9972211,0.0006745524,0.000121702,0.001185893],"study_design_scores_gemma":[0.0001273276,0.0006000747,0.0015487,0.00002989789,0.00006075472,0.0007439797,0.0000315373,0.001247103,0.9899441,0.0002134994,0.005433962,0.00001904717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.971826,0.002023538,0.01463811,0.001311939,0.0002953972,0.0003741147,0.004378007,0.000832659,0.004320202],"genre_scores_gemma":[0.9419053,0.002674663,0.02943941,0.0003231991,0.00008772908,0.0007222312,0.003461577,0.0004625143,0.02092352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003344935,"threshold_uncertainty_score":0.01118988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03899790878574015,"score_gpt":0.3107919561118662,"score_spread":0.2717940473261261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}