{"id":"W2164569166","doi":"10.1016/j.jmb.2003.09.046","title":"A Thermodynamic Basis of DNA Sequence Selectivity by the ETS Domain of Murine PU.1","year":2003,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"DNA; DNA-binding domain; Chemistry; Biophysics; Transcription factor; Computational biology; Biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005745003,0.0002270131,0.000322226,0.0002952954,0.0004750979,0.0005332472,0.0004907327,0.000262998,0.002790706],"category_scores_gemma":[0.001091932,0.000319889,0.0001356987,0.0001202499,0.0005895661,0.0004970597,0.0003649112,0.0005602503,0.0004990839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003463381,"about_ca_system_score_gemma":0.0003366608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000347555,"about_ca_topic_score_gemma":0.0006641928,"domain_scores_codex":[0.9997473,0.00004836721,0.00001237363,0.00005315321,0.00007950424,0.00005927266],"domain_scores_gemma":[0.999312,0.0003144332,0.000107223,0.00005127266,0.00009199965,0.0001230901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003553793,0.00005142356,0.002086135,0.00005731272,0.00001123055,0.00007144597,0.00004594423,0.002158328,0.9836076,0.006756503,0.0001475733,0.004650989],"study_design_scores_gemma":[0.00006468831,0.0003387948,0.008567318,0.000009139464,0.00001709717,0.0003282419,0.00007885697,0.01755986,0.9669504,0.004848678,0.001199306,0.00003768252],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920352,0.0003790801,0.005425827,0.0001290774,0.00003259407,0.00001276393,0.00006075245,0.00007847642,0.001846302],"genre_scores_gemma":[0.999045,0.00007489575,0.0005080513,0.00002191293,0.00001100929,0.000007041513,0.00005194407,0.0000217797,0.0002584599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002790706,"threshold_uncertainty_score":0.009335876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005112583068002905,"score_gpt":0.2379181733855375,"score_spread":0.2328055903175346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}