{"id":"W2164571519","doi":"10.1002/hon.2251","title":"Concomitant high expression of Toll‐like receptor (TLR) and B‐cell receptor (BCR) signalling molecules has clinical implications in mantle cell lymphoma","year":2015,"lang":"en","type":"article","venue":"Hematological Oncology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Calgary Laboratory Services; University of Alberta; Alberta Cancer Foundation; University of Calgary","funders":"Alberta Cancer Foundation; Calgary Laboratory Services","keywords":"breakpoint cluster region; Cancer research; Syk; Biology; B-cell receptor; Mantle cell lymphoma; Toll-like receptor; Signal transduction; TLR7; Bruton's tyrosine kinase; TLR9; Receptor; Immunology; B cell; Gene expression; Cell biology; Innate immune system; Immune system; Gene; Lymphoma; Genetics; Tyrosine kinase; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001745022,0.0001357667,0.0001637098,0.0003593329,0.0001664203,0.0003137462,0.00007978546,0.0002016147,0.001654327],"category_scores_gemma":[0.0002757519,0.00007781714,0.0001215805,0.0003468458,0.0001894609,0.0001142718,0.0002104207,0.0002710008,0.0002439066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001357008,"about_ca_system_score_gemma":0.00006948889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002639148,"about_ca_topic_score_gemma":0.0002568227,"domain_scores_codex":[0.9998552,0.00003052039,0.00001078162,0.00003484753,0.00002769484,0.00004104073],"domain_scores_gemma":[0.9998083,0.00004881903,0.00006937737,0.00001639984,0.00001579743,0.00004133951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001588956,0.0001142429,0.2855743,0.0001406581,0.00005991543,0.0005531712,0.0001970789,0.0005430687,0.6947483,0.0001338073,0.0002560843,0.01609045],"study_design_scores_gemma":[0.00002587967,0.0006565985,0.9329234,0.00001329283,0.00006169728,0.002084345,0.0002992035,0.001513948,0.06055477,0.0002926309,0.001565574,0.000008793551],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987802,0.0003215617,0.000387433,0.00001947422,0.000002058748,0.00000625149,0.0001564253,0.000009739499,0.0003167747],"genre_scores_gemma":[0.999428,0.0000524296,0.0001983899,0.00001124115,0.000003033593,0.000007614184,0.0001550825,0.000001391136,0.0001427938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001654327,"threshold_uncertainty_score":0.005534291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08521364045476884,"score_gpt":0.3416249336855472,"score_spread":0.2564112932307784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}