{"id":"W2164584401","doi":"10.1016/j.jhep.2005.12.011","title":"A phase 2 study to evaluate the antiviral activity, safety, and pharmacokinetics of recombinant human albumin-interferon alfa fusion protein in genotype 1 chronic hepatitis C patients","year":2006,"lang":"en","type":"article","venue":"Journal of Hepatology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":92,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University of British Columbia; University of Manitoba; University of Calgary; University of Alberta","funders":"","keywords":"Medicine; Pharmacokinetics; Interferon alfa; Chills; Adverse effect; Hepatitis C virus; Internal medicine; Albumin; Recombinant DNA; Interferon; Gastroenterology; Alpha interferon; Hepatitis C; Immunology; Pharmacology; Hepacivirus; Serum albumin; Virus; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001809729,0.001871443,0.002409634,0.0003867096,0.0006485283,0.0007975119,0.0005920818,0.001562279,0.002425429],"category_scores_gemma":[0.001410438,0.0007356142,0.001267639,0.0003616156,0.001302524,0.001210275,0.000262677,0.00289263,0.0006495314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001190888,"about_ca_system_score_gemma":0.001612514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001160022,"about_ca_topic_score_gemma":0.001318395,"domain_scores_codex":[0.999429,0.0002669463,0.00001784667,0.0001003002,0.00004599261,0.000139849],"domain_scores_gemma":[0.9990109,0.000242105,0.0001708719,0.0001119157,0.00005786458,0.0004062608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7905697,0.07813737,0.008614909,0.0002913427,0.0007757877,0.0005393279,0.0005249501,0.002704274,0.06939387,0.0003384345,0.002166097,0.04594386],"study_design_scores_gemma":[0.4092834,0.5729287,0.01011011,0.00001097421,0.0002449145,0.0004526146,0.00006537075,0.001252856,0.004319954,0.0001864521,0.001109481,0.00003517026],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972689,0.0003938804,0.0004374918,0.0002552197,0.00006372994,0.0008403809,0.000278865,0.00004912238,0.0004124027],"genre_scores_gemma":[0.9941279,0.0003640948,0.00110766,0.0005669197,0.0001604902,0.00152299,0.00090747,0.00003608394,0.001206388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002425429,"threshold_uncertainty_score":0.009570897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02782899388369951,"score_gpt":0.3755244546890629,"score_spread":0.3476954608053633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}