{"id":"W2164590798","doi":"10.1016/j.bmcl.2006.12.005","title":"Structure–activity relationships of 3-aminoquinazolinediones, a new class of bacterial type-2 topoisomerase (DNA gyrase and topo IV) inhibitors","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"DNA gyrase; Chemistry; Topoisomerase; Topoisomerase IV; Stereochemistry; Enzyme; Antibacterial activity; DNA; Structure–activity relationship; Antibacterial agent; Potency; IC50; Enzyme inhibitor; Escherichia coli; Biochemistry; Bacteria; In vitro; Antibiotics; Genetics; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002812556,0.0002382292,0.0002688191,0.0001812077,0.00007071104,0.0002227844,0.0002492732,0.0002150275,0.0008647071],"category_scores_gemma":[0.0002669666,0.0001228851,0.0001811586,0.00009604561,0.0001190776,0.0001406265,0.00007422211,0.0002731872,0.0001850459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002858475,"about_ca_system_score_gemma":0.0001195377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009593419,"about_ca_topic_score_gemma":0.001677421,"domain_scores_codex":[0.9998815,0.0000360541,0.000008957934,0.00001669236,0.00003120966,0.0000256102],"domain_scores_gemma":[0.9998697,0.00003542735,0.00003108311,0.000006788642,0.00002335364,0.00003360623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002343494,0.0002717753,0.001405655,0.000115176,0.00005993934,0.000186131,0.00005257651,0.003569973,0.9768817,0.0002967293,0.0004659868,0.0143508],"study_design_scores_gemma":[0.0009112455,0.01524281,0.01460818,0.0000261236,0.0001995483,0.001376339,0.00004179507,0.01133809,0.9445894,0.0001635176,0.01144767,0.00005530809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854224,0.01134765,0.001136386,0.0001145406,0.00003248725,0.00003095385,0.00030554,0.00006614751,0.001543783],"genre_scores_gemma":[0.995418,0.002432307,0.0006394797,0.00004786262,0.00001265586,0.00001117469,0.0004579588,0.000005619067,0.0009750198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009593419,"threshold_uncertainty_score":0.002892733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009390209359496289,"score_gpt":0.2131479775257392,"score_spread":0.203757768166243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}